Feasibility of assessing autonomic dysregulation at a distance: the case of the HIV-positive patient.

Mara Malacarne, Antonietta Cargnel, Daniela Lucini, Paolo Pizzinelli, Alberto Porta, Massimo Pagani

Research output: Contribution to journalArticle

Abstract

Alterations in lipid metabolism are a possible consequence of highly active antiretroviral therapies (HAART) for human immunodeficiency virus (HIV)-positive patients with consequent increase of cardiovascular risk. In this context we hypothesized that both acquired immunodeficiency syndrome (AIDS) and HAART might be associated to alterations in autonomic cardiovascular regulation. In this preliminary investigation we enrolled a total of 66 men, subdivided in two groups, 33 HIV-positive patients, and 33 healthy controls, and we tested the hypothesis that heart rate variability (HRV) of HIV positive patients can be assessed with a transtelephonic approach from the HIV clinic: 100% of the total of electrocardiograms (ECG) recordings that were sent from the distant site were successfully received and analyzed. Evaluation of the signal was subsequently performed in the centralized laboratory, and consisted in extracting the RR interval variability (RRV) series and afterward subjecting it to autoregressive spectral analysis. This study shows the feasibility of obtaining, from personnel without specific training, adequate RR variability data for further spectral analysis form a distant specialized autonomic laboratory. This feature is of critical importance in the context of possible large-scale application of this simple telemedicine approach.

Original languageEnglish
Pages (from-to)557-563
Number of pages7
JournalTelemedicine journal and e-health : the official journal of the American Telemedicine Association
Volume13
Issue number5
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Viruses
HIV
Highly Active Antiretroviral Therapy
Spectrum analysis
Telemedicine
Feasibility Studies
Electrocardiography
Lipid Metabolism
Acquired Immunodeficiency Syndrome
Heart Rate
Personnel

ASJC Scopus subject areas

  • Medicine(all)
  • Bioengineering
  • Media Technology
  • Nursing(all)

Cite this

Feasibility of assessing autonomic dysregulation at a distance : the case of the HIV-positive patient. / Malacarne, Mara; Cargnel, Antonietta; Lucini, Daniela; Pizzinelli, Paolo; Porta, Alberto; Pagani, Massimo.

In: Telemedicine journal and e-health : the official journal of the American Telemedicine Association, Vol. 13, No. 5, 10.2007, p. 557-563.

Research output: Contribution to journalArticle

@article{b0d246f05597405597ea2946ff99dab9,
title = "Feasibility of assessing autonomic dysregulation at a distance: the case of the HIV-positive patient.",
abstract = "Alterations in lipid metabolism are a possible consequence of highly active antiretroviral therapies (HAART) for human immunodeficiency virus (HIV)-positive patients with consequent increase of cardiovascular risk. In this context we hypothesized that both acquired immunodeficiency syndrome (AIDS) and HAART might be associated to alterations in autonomic cardiovascular regulation. In this preliminary investigation we enrolled a total of 66 men, subdivided in two groups, 33 HIV-positive patients, and 33 healthy controls, and we tested the hypothesis that heart rate variability (HRV) of HIV positive patients can be assessed with a transtelephonic approach from the HIV clinic: 100{\%} of the total of electrocardiograms (ECG) recordings that were sent from the distant site were successfully received and analyzed. Evaluation of the signal was subsequently performed in the centralized laboratory, and consisted in extracting the RR interval variability (RRV) series and afterward subjecting it to autoregressive spectral analysis. This study shows the feasibility of obtaining, from personnel without specific training, adequate RR variability data for further spectral analysis form a distant specialized autonomic laboratory. This feature is of critical importance in the context of possible large-scale application of this simple telemedicine approach.",
author = "Mara Malacarne and Antonietta Cargnel and Daniela Lucini and Paolo Pizzinelli and Alberto Porta and Massimo Pagani",
year = "2007",
month = "10",
doi = "10.1089/tmj.2006.0092",
language = "English",
volume = "13",
pages = "557--563",
journal = "Telemedicine Journal and e-Health",
issn = "1530-5627",
publisher = "Mary Ann Liebert Inc.",
number = "5",

}

TY - JOUR

T1 - Feasibility of assessing autonomic dysregulation at a distance

T2 - the case of the HIV-positive patient.

AU - Malacarne, Mara

AU - Cargnel, Antonietta

AU - Lucini, Daniela

AU - Pizzinelli, Paolo

AU - Porta, Alberto

AU - Pagani, Massimo

PY - 2007/10

Y1 - 2007/10

N2 - Alterations in lipid metabolism are a possible consequence of highly active antiretroviral therapies (HAART) for human immunodeficiency virus (HIV)-positive patients with consequent increase of cardiovascular risk. In this context we hypothesized that both acquired immunodeficiency syndrome (AIDS) and HAART might be associated to alterations in autonomic cardiovascular regulation. In this preliminary investigation we enrolled a total of 66 men, subdivided in two groups, 33 HIV-positive patients, and 33 healthy controls, and we tested the hypothesis that heart rate variability (HRV) of HIV positive patients can be assessed with a transtelephonic approach from the HIV clinic: 100% of the total of electrocardiograms (ECG) recordings that were sent from the distant site were successfully received and analyzed. Evaluation of the signal was subsequently performed in the centralized laboratory, and consisted in extracting the RR interval variability (RRV) series and afterward subjecting it to autoregressive spectral analysis. This study shows the feasibility of obtaining, from personnel without specific training, adequate RR variability data for further spectral analysis form a distant specialized autonomic laboratory. This feature is of critical importance in the context of possible large-scale application of this simple telemedicine approach.

AB - Alterations in lipid metabolism are a possible consequence of highly active antiretroviral therapies (HAART) for human immunodeficiency virus (HIV)-positive patients with consequent increase of cardiovascular risk. In this context we hypothesized that both acquired immunodeficiency syndrome (AIDS) and HAART might be associated to alterations in autonomic cardiovascular regulation. In this preliminary investigation we enrolled a total of 66 men, subdivided in two groups, 33 HIV-positive patients, and 33 healthy controls, and we tested the hypothesis that heart rate variability (HRV) of HIV positive patients can be assessed with a transtelephonic approach from the HIV clinic: 100% of the total of electrocardiograms (ECG) recordings that were sent from the distant site were successfully received and analyzed. Evaluation of the signal was subsequently performed in the centralized laboratory, and consisted in extracting the RR interval variability (RRV) series and afterward subjecting it to autoregressive spectral analysis. This study shows the feasibility of obtaining, from personnel without specific training, adequate RR variability data for further spectral analysis form a distant specialized autonomic laboratory. This feature is of critical importance in the context of possible large-scale application of this simple telemedicine approach.

UR - http://www.scopus.com/inward/record.url?scp=38449102823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449102823&partnerID=8YFLogxK

U2 - 10.1089/tmj.2006.0092

DO - 10.1089/tmj.2006.0092

M3 - Article

C2 - 17999617

AN - SCOPUS:38349174421

VL - 13

SP - 557

EP - 563

JO - Telemedicine Journal and e-Health

JF - Telemedicine Journal and e-Health

SN - 1530-5627

IS - 5

ER -