Microcytosis is a common hematological finding, usually related to iron deficiency or β-thalassemia. When both of these conditions are excluded, α- thalassemia must be considered in the differential diagnosis. No simple biochemical test is able to diagnose the α-thalassemia trait. Using PCR amplification of the breakpoint in deletional forms, and amplification of the α2 gene and restriction enzyme digestion in non-deletional forms, we identified the α-thalassemia carrier status in 42 our of 51 (82%) patients with microcytosis or slight microcytic anemia, unrelated to iron deficiency or β-thalassemia. Our results underline the usefulness of molecular tests in clinical practice.
|Number of pages||2|
|Publication status||Published - Sep 1997|
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