Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia: A pilot study from the gimema group

Marco Montillo, Alessandra Tedeschi, Livio Pagano, Adriano Venditti, Felicetto Ferrara, Piero Fabris, Bruno Martino, Maurizio Musso, Gennaro De Rosa, Giorgina Specchia, Michele Monaco, Giovanni Sparaventi, Antonio Spadea, Angelo Palmas, Wilma Deplano, Annunziata Manna, Lorella Melillo, Eustachio Miraglia, Salvatore Mirto, Franco Mandelli

Research output: Contribution to journalArticle

Abstract

Elderly patients with untreated acute myeloid leukaemia (AML, n = 47) tested the feasibility of out-patient consolidation therapy and post-consolidation treatment (for patients aged <71 years) with autologous peripheral blood stem cell transplantation (APBSCT). Overall, 13 patients out of 24 (51%) who achieved complete remission (CR) were eligible for further treatment after consolidation. Five patients were primed with granulocyte colony stimulating factor (G-CSF); a suitable number of CD34 + cells were harvested in three patients and were actually autotrans-planted. The toxicity of APBSCT was negligible. Psychosocial problems impaired treatment of some patients on an out-patient basis. Resistant disease, toxicity and logistic problems reduced the number of patients to whom this procedure could actually be applied.

Original languageEnglish
Pages (from-to)334-337
Number of pages4
JournalBritish Journal of Haematology
Volume111
Issue number1
DOIs
Publication statusPublished - 2000

    Fingerprint

Keywords

  • Acute myeloid leukaemia
  • Elderly patients
  • Peripheral blood stem cell support

ASJC Scopus subject areas

  • Hematology

Cite this

Montillo, M., Tedeschi, A., Pagano, L., Venditti, A., Ferrara, F., Fabris, P., Martino, B., Musso, M., De Rosa, G., Specchia, G., Monaco, M., Sparaventi, G., Spadea, A., Palmas, A., Deplano, W., Manna, A., Melillo, L., Miraglia, E., Mirto, S., & Mandelli, F. (2000). Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia: A pilot study from the gimema group. British Journal of Haematology, 111(1), 334-337. https://doi.org/10.1046/j.1365-2141.2000.02277.x