Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples

F. Barbieri, G. Parodi, T. Massa, M. Cagnoli, G. Barbi, A. Imperiale, A. Alama

Research output: Contribution to journalArticle

Abstract

Fine-needle aspiration (FNA) provides a suitable diagnostic tool in the management of patients with breast cancer lesions. The current study reports on tumor proliferative activity, by 3H-Thymidine Labelling Index (TLI), assessed on 59 FNA (TLI1) and 28 surgical specimens (TLI2) from the same breast cancer patients. Median TLI values from FNA and surgical material were 1.0% and 0.7%, respectively. In the 28 patients, evaluable for the comparison between TLI1 and TLI2, the association was found to be highly significant (p = 0.000). Moreover, no change in tumor proliferative activity was observed in the majority (79%) of cases when evaluated preoperatively and at surgery. This study confirms the feasibility of TLI analysis on FNA from breast cancer and provides results superimposable on those obtained in a tissue sample from the same patient.

Original languageEnglish
Pages (from-to)1973-1977
Number of pages5
JournalAnticancer Research
Volume14
Issue number5 A
Publication statusPublished - 1994

Keywords

  • Breast cancer
  • Fine needle aspiration
  • Thymidine labelling index

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Barbieri, F., Parodi, G., Massa, T., Cagnoli, M., Barbi, G., Imperiale, A., & Alama, A. (1994). Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples. Anticancer Research, 14(5 A), 1973-1977.