Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples

F. Barbieri, G. Parodi, T. Massa, M. Cagnoli, G. Barbi, A. Imperiale, A. Alama

Research output: Contribution to journalArticle

Abstract

Fine-needle aspiration (FNA) provides a suitable diagnostic tool in the management of patients with breast cancer lesions. The current study reports on tumor proliferative activity, by 3H-Thymidine Labelling Index (TLI), assessed on 59 FNA (TLI1) and 28 surgical specimens (TLI2) from the same breast cancer patients. Median TLI values from FNA and surgical material were 1.0% and 0.7%, respectively. In the 28 patients, evaluable for the comparison between TLI1 and TLI2, the association was found to be highly significant (p = 0.000). Moreover, no change in tumor proliferative activity was observed in the majority (79%) of cases when evaluated preoperatively and at surgery. This study confirms the feasibility of TLI analysis on FNA from breast cancer and provides results superimposable on those obtained in a tissue sample from the same patient.

Original languageEnglish
Pages (from-to)1973-1977
Number of pages5
JournalAnticancer Research
Volume14
Issue number5 A
Publication statusPublished - 1994

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Fine Needle Biopsy
Thymidine
Needles
Breast Neoplasms
Feasibility Studies
Neoplasms

Keywords

  • Breast cancer
  • Fine needle aspiration
  • Thymidine labelling index

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Barbieri, F., Parodi, G., Massa, T., Cagnoli, M., Barbi, G., Imperiale, A., & Alama, A. (1994). Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples. Anticancer Research, 14(5 A), 1973-1977.

Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer : Comparison with surgical samples. / Barbieri, F.; Parodi, G.; Massa, T.; Cagnoli, M.; Barbi, G.; Imperiale, A.; Alama, A.

In: Anticancer Research, Vol. 14, No. 5 A, 1994, p. 1973-1977.

Research output: Contribution to journalArticle

Barbieri, F, Parodi, G, Massa, T, Cagnoli, M, Barbi, G, Imperiale, A & Alama, A 1994, 'Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples', Anticancer Research, vol. 14, no. 5 A, pp. 1973-1977.
Barbieri F, Parodi G, Massa T, Cagnoli M, Barbi G, Imperiale A et al. Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer: Comparison with surgical samples. Anticancer Research. 1994;14(5 A):1973-1977.
Barbieri, F. ; Parodi, G. ; Massa, T. ; Cagnoli, M. ; Barbi, G. ; Imperiale, A. ; Alama, A. / Feasibility of Thymidine Labelling Index on fine needle aspirates from breast cancer : Comparison with surgical samples. In: Anticancer Research. 1994 ; Vol. 14, No. 5 A. pp. 1973-1977.
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