Feasibility randomized trial for an intensive memory-focused training program for school-aged children with acquired brain injury

Monica Recla, Erika Molteni, Valentina Manfredi, Filippo Arrigoni, Andrea Nordio, Susanna Galbiati, Valentina Pastore, Marc Modat, Sandra Strazzer

Research output: Contribution to journalArticlepeer-review

Abstract

(1) Background: Memory deficits are common sequelae of pediatric Acquired Brain Injury (ABI). Only methods for non-focused cognitive remediation are available to the pediatric field. The aims of this feasibility trial are the description, implementation, and test of an intensive program specific to the training and re-adaptation of memory function in children, called Intensive Memory-Focused Training Program (IM-FTP); (2) Methods: Eleven children and adolescents with ABI (mean age at injury = 12.2 years, brain tumor survivors excluded) were clinically assessed and rehabilitated over 1-month through IM-FTP, including physio-kinesis/occupational, speech, and neuropsychology treatments. Each patient received a psychometric evaluation and a brain functional MRI at enrollment and at discharge. Ten pediatric controls with ABI (mean age at injury = 13.8 years) were clinically assessed, and rehabilitated through a standard program; (3) Results: After treatment, both groups had marked improvement in both immediate and delayed recall. IM-FTP was associated with better learning of semantically related and unrelated words, and larger improvement in immediate recall in prose memory. Imaging showed functional modification in the left frontal inferior cortex; (4) Conclusions: We described an age-independent reproducible multidisciplinary memory-focused rehabilitation protocol, which can be adapted to single patients while preserving inter-subject comparability, and is applicable up to a few months after injury. IM-FTP will now be employed in a powered clinical trial.

Original languageEnglish
Article number430
Number of pages20
JournalBrain Sciences
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Child
  • Immediate and delayed recall
  • Left inferior frontal gyrus
  • Memory
  • Pediatric brain injury
  • Rehabilitation

ASJC Scopus subject areas

  • Neuroscience(all)

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