Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases

G. J. Bakeine; M. Di Salvo; S. Bortolussi; S. Stella; P. Bruschi; A. Bertolotti; R. Nano; A. Clerici; C. Ferrari; C. Zonta; A. Marchetti; S. Altieri

doi:10.1016/j.apradiso.2009.03.073

Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases

G. J. Bakeine, M. Di Salvo, S. Bortolussi, S. Stella, P. Bruschi, A. Bertolotti, R. Nano, A. Clerici, C. Ferrari, C. Zonta, A. Marchetti, S. Altieri

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

In order for boron neutron capture therapy (BNCT) to be eligible for application in lung tumour disease, three fundamental criteria must be fulfilled: there must be selective uptake of boron in the tumour cells with respect to surrounding healthy tissue, biological effectiveness of the radiation therapy and minimal damage or collateral effects of the irradiation on the surrounding tissues. In this study, we evaluated the biological effectiveness of BNCT by in vitro irradiation of rat colon-carcinoma cells previously incubated in boron-enriched medium. One part of these cells was re-cultured in vitro while the other was inoculated via the inferior vena cava to induce pulmonary metastases in a rat model. We observed a post-irradiation in vitro cell viability of 0.05% after 8 days of cell culture. At 4 months follow-up, all animal subjects in the treatment group that received irradiated boron-containing cells were alive. No animal survived beyond 1 month in the control group that received non-treated cells (p

Original language	English
Journal	Applied Radiation and Isotopes
Volume	67
Issue number	7-8 SUPPL.
DOIs	https://doi.org/10.1016/j.apradiso.2009.03.073
Publication status	Published - Jul 2009

Keywords

Animal model
BNCT
Lung metastases

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2009.03.073

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Bakeine, G. J., Di Salvo, M., Bortolussi, S., Stella, S., Bruschi, P., Bertolotti, A., Nano, R., Clerici, A., Ferrari, C., Zonta, C., Marchetti, A., & Altieri, S. (2009). Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases. Applied Radiation and Isotopes, 67(7-8 SUPPL.). https://doi.org/10.1016/j.apradiso.2009.03.073

Bakeine, GJ, Di Salvo, M, Bortolussi, S, Stella, S, Bruschi, P, Bertolotti, A, Nano, R, Clerici, A, Ferrari, C, Zonta, C, Marchetti, A & Altieri, S 2009, 'Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases', Applied Radiation and Isotopes, vol. 67, no. 7-8 SUPPL. https://doi.org/10.1016/j.apradiso.2009.03.073

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abstract = "In order for boron neutron capture therapy (BNCT) to be eligible for application in lung tumour disease, three fundamental criteria must be fulfilled: there must be selective uptake of boron in the tumour cells with respect to surrounding healthy tissue, biological effectiveness of the radiation therapy and minimal damage or collateral effects of the irradiation on the surrounding tissues. In this study, we evaluated the biological effectiveness of BNCT by in vitro irradiation of rat colon-carcinoma cells previously incubated in boron-enriched medium. One part of these cells was re-cultured in vitro while the other was inoculated via the inferior vena cava to induce pulmonary metastases in a rat model. We observed a post-irradiation in vitro cell viability of 0.05% after 8 days of cell culture. At 4 months follow-up, all animal subjects in the treatment group that received irradiated boron-containing cells were alive. No animal survived beyond 1 month in the control group that received non-treated cells (p",

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AU - Stella, S.

AU - Bruschi, P.

AU - Bertolotti, A.

AU - Nano, R.

AU - Clerici, A.

AU - Ferrari, C.

AU - Zonta, C.

AU - Marchetti, A.

AU - Altieri, S.

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Feasibility study on the utilization of boron neutron capture therapy (BNCT) in a rat model of diffuse lung metastases

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