Fecal calprotectin concentrations in alcoholic patients

A longitudinal study

Massimo Montalto, Antonella Gallo, Anna Ferrulli, Dina Visca, Elena Campobasso, Silvia Cardone, Ferruccio D'Onofrio, Luca Santoro, Marcello Covino, Antonio Mirijello, Lorenzo Leggio, Giovanni Gasbarrini, Giovanni Addolorato

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Excessive alcohol consumption often Results in intestinal damage, mediated by inflammatory processes, mainly characterized by an increased influx of leukocytes. Fecal calprotectin is a granulocyte cytosolic protein, representing as a promising marker of subclinical intestinal inflammation. In this study, we assessed fecal calprotectin concentrations (FCCs) in current drinking alcoholics, both at the baseline, and then during a subsequent 84-day period. Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls. Methods: Twenty-eight, active-drinking alcoholics were enrolled in this study and compared with 40 healthy volunteers as the control group. In alcoholics, FCCs were determined at the beginning of the study (baseline; T0) and then every 2 weeks (T1-T6) during the following 84-day period. Potential differences in FCCs were analyzed between alcoholics and healthy controls, and during the 84-day period within the group of alcoholics. In addition, an analysis of FCCs was conducted in three subgroups of alcoholics, considering their drinking status during the 84-day period (abstinent, relapsed, and active). Results: At baseline, no significant differences in median FCCs were found between alcoholics and controls. No significant changes of median FCCs were found, comparing baseline FCCs and FCCs during the 84-day period (T1-T6) in the whole group of alcoholics, nor in the three subgroups of alcoholics. Conclusion: FCCs in active-drinking alcoholics are not significantly different, compared with the healthy controls. Moreover, FCCs do not significantly differ according to the alcohol drinking status. These Results may suggest the absence of a subclinal intestinal inflammation involving neutrophils in the alcoholics.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Leukocyte L1 Antigen Complex
Alcoholics
Longitudinal Studies
Drinking
Alcohol Drinking
Inflammation
Granulocytes

Keywords

  • alcohol abuse
  • fecal calprotectin
  • gut inflammation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Fecal calprotectin concentrations in alcoholic patients : A longitudinal study. / Montalto, Massimo; Gallo, Antonella; Ferrulli, Anna; Visca, Dina; Campobasso, Elena; Cardone, Silvia; D'Onofrio, Ferruccio; Santoro, Luca; Covino, Marcello; Mirijello, Antonio; Leggio, Lorenzo; Gasbarrini, Giovanni; Addolorato, Giovanni.

In: European Journal of Gastroenterology and Hepatology, Vol. 23, No. 1, 01.2011, p. 76-80.

Research output: Contribution to journalArticle

Montalto, M, Gallo, A, Ferrulli, A, Visca, D, Campobasso, E, Cardone, S, D'Onofrio, F, Santoro, L, Covino, M, Mirijello, A, Leggio, L, Gasbarrini, G & Addolorato, G 2011, 'Fecal calprotectin concentrations in alcoholic patients: A longitudinal study', European Journal of Gastroenterology and Hepatology, vol. 23, no. 1, pp. 76-80. https://doi.org/10.1097/MEG.0b013e32834101f9
Montalto, Massimo ; Gallo, Antonella ; Ferrulli, Anna ; Visca, Dina ; Campobasso, Elena ; Cardone, Silvia ; D'Onofrio, Ferruccio ; Santoro, Luca ; Covino, Marcello ; Mirijello, Antonio ; Leggio, Lorenzo ; Gasbarrini, Giovanni ; Addolorato, Giovanni. / Fecal calprotectin concentrations in alcoholic patients : A longitudinal study. In: European Journal of Gastroenterology and Hepatology. 2011 ; Vol. 23, No. 1. pp. 76-80.
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