Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease

Marco Scarpa, Renata D'Incà, Daniela Basso, Cesare Ruffolo, Lino Polese, Eugenia Bertin, Alessia Luise, Mauro Frego, Mario Plebani, Giacomo C. Sturniolo, Davide F. D'Amico, Imerio Angriman

Research output: Contribution to journalArticle

Abstract

PURPOSE: This study was designed to assess the role of fecal lactoferrin and calprotectin as markers of intestinal inflammation in patients with Crohn's disease who have undergone ileocolonic resection. METHODS: Sixty-three patients who had undergone ileocolonic resection for Crohn's disease with a median follow-up of 40.5 (range, 5-102) months were enrolled. Clinical examination and blood test were performed, and fecal lactoferrin and calprotectin levels were dosed. The predictors for fecal lactoferrin and calprotectin levels that resulted to be significant at the univariate analyses were included in two multiple regression analysis models. RESULTS: The mean lactoferrin level was 21±3.9 μg/g and the mean calprotectin fecal level was 247±22.7 ng/ml. C-reactive protein levels (P

Original languageEnglish
Pages (from-to)861-869
Number of pages9
JournalDiseases of the Colon and Rectum
Volume50
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • C-reactive protein
  • Calprotectin
  • Crohn's disease
  • Lactoferrin
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

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    Scarpa, M., D'Incà, R., Basso, D., Ruffolo, C., Polese, L., Bertin, E., Luise, A., Frego, M., Plebani, M., Sturniolo, G. C., D'Amico, D. F., & Angriman, I. (2007). Fecal lactoferrin and calprotectin after ileocolonic resection for Crohn's disease. Diseases of the Colon and Rectum, 50(6), 861-869. https://doi.org/10.1007/s10350-007-0225-6