TY - JOUR
T1 - Fecal micrornas as innovative biomarkers of intestinal diseases and effective players in hostmicrobiome interactions
AU - Sarshar, Meysam
AU - Scribano, Daniela
AU - Ambrosi, Cecilia
AU - Palamara, Anna Teresa
AU - Masotti, Andrea
N1 - Funding Information:
Funding: Ministry of Health is gratefully acknowledged for financial support (Project M.S.). Salary of D.S. was supported by the Dani Di Giò Foundation-Onlus, Rome, Italy.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8
Y1 - 2020/8
N2 - Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identified dysregulated fecal miRNAs in intestinal diseases, with particular focus on colorectal cancer (CRC) and celiac disease (CD). The aim of this review is to highlight one fascinating aspect of fecal miRNA function related to gut microbiota shaping and bacterial metabolism influencing. The role of miRNAs as “messenger” molecules for inter kingdom communications will be analyzed to highlight their role in the complex host-bacteria interactions. Moreover, whether fecal miRNAs could open up new perspectives to develop novel suitable biomarkers for disease detection and innovative therapeutic approaches to restore microbiota balance will be discussed.
AB - Over the past decade, short non-coding microRNAs (miRNAs), including circulating and fecal miRNAs have emerged as important modulators of various cellular processes by regulating the expression of target genes. Recent studies revealed the role of miRNAs as powerful biomarkers in disease diagnosis and for the development of innovative therapeutic applications in several human conditions, including intestinal diseases. In this review, we explored the literature and summarized the role of identified dysregulated fecal miRNAs in intestinal diseases, with particular focus on colorectal cancer (CRC) and celiac disease (CD). The aim of this review is to highlight one fascinating aspect of fecal miRNA function related to gut microbiota shaping and bacterial metabolism influencing. The role of miRNAs as “messenger” molecules for inter kingdom communications will be analyzed to highlight their role in the complex host-bacteria interactions. Moreover, whether fecal miRNAs could open up new perspectives to develop novel suitable biomarkers for disease detection and innovative therapeutic approaches to restore microbiota balance will be discussed.
KW - Bacterial small RNAs
KW - Biomarkers
KW - Celiac disease
KW - Colorectal cancer
KW - Extracellular vesicles
KW - Fecal microRNAs
KW - Host-microbiome interplay
KW - Small non-coding RNAs
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U2 - 10.3390/cancers12082174
DO - 10.3390/cancers12082174
M3 - Review article
AN - SCOPUS:85090508282
VL - 12
SP - 1
EP - 21
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 8
M1 - 2174
ER -