Il felbamato in add-on nel trattamento delle epilessie sintomatiche farmacoresistenti

Translated title of the contribution: Felbamate as add-on therapy of the refractory symptomatic epilepsies

M. Bottitta, S. A. Musumeci, R. Ferri, C. Scuderi, S. Fausti, S. Del Gracco, M. Elia

Research output: Contribution to journalArticle

Abstract

Twenty-three patients (14 males and 9 females, mean age 16.6 years, range 3-37 years) with refractory symptomatic partial or generalized epilepsy received open-label felbamate (FBM) as an add-on therapy to their background antiepileptic drugs. The mean FBM daily dose was 36.1 mg/kg/day (range 13- 45). The mean duration of FBM treatment was 12.3 months (range 2-24). Fifteen patients (65.2%) are still receiving FBM, and 8 (34.8%) have withdrawn for lack of efficacy or poor compliance. Of the 23 patients 7 (30.4%) achieved a seizure reduction of 50% or more, including 2 subjects who were seizure-free (8.7%). No severe adverse effects were observed. Weight loss (21.7%) and anorexia (17.4%) were the most frequently reported adverse effects. We conclude that FBM can be considered a useful add-on treatment of the refractory symptomatic epilepsies, also in the long term.

Translated title of the contributionFelbamate as add-on therapy of the refractory symptomatic epilepsies
Original languageItalian
Pages (from-to)179-181
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number99
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology

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