FEME, BAFME, FAME, FCTE, ADCME,.. Lo spettro dell'Epilessia Mioclonica Familiare Benigna dell'Adulto: Review dei casi della letteratura

Benign Adult Familial Myoclonic Epilepsy is an AD syndrome characterized from a non progressive cortical tremor resembling essential tremor, myoclonus and rare GTCS, first described from Japanese AA. Despite the different acronyms used (FEME, FCTE, BAFME, FAME), it seems to be a well definite clinical picture. Recently, non-Japanese families with similar phenotype, have been also described. We have already reported two, and recently observed a third, Italian families with linkage to chromosome 2p11.1-q12.2. In our opinion, this syndrome has a worldwide diffusion; it is genetically heterogeneous and might be overlooked.