Femtosecond laser-assisted lamellar keratoplasty

Early results

Luigi Mosca, Romina Fasciani, Ciro Tamburelli, Luca Buzzonetti, Laura Guccione, Erika Mandarà, Emilio Balestrazzi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

PURPOSE: To evaluate the outcomes and safety of lamellar keratoplasty (LK) assisted by a femtosecond laser. METHODS: Twenty-one eyes of 21 patients affected by different corneal pathologies (5 posttraumatic corneal scar, 3 postkeratitis corneal leucoma, and 13 keratoconus) underwent LK procedures by using a femtosecond laser. The mean thinnest corneal thickness, evaluated with ultrasound corneal pachymetry and with confocal microscopy, was 434.19 ± 62.60 (SD) μm (range, 333-548 μm). Mean preoperative uncorrected visual acuity was 0.09 ± 0.28 SD and mean preoperative best spectacle-corrected visual acuity was 0.28 ± 0.15 SD. A femtosecond laser was used to perform corneal cuts on both donor and recipient corneas. The donor corneal lamella diameters were 0.20-mm larger and thicker than the recipient to restore a physiologic corneal thickness and shape: mean donor diameter was 8.34 ± 0.28 mm (range, 8.2-8.7 mm) and mean thickness was 352 ± 40.27 μm (range, 220-400 μm). Mean follow-up was 20.86 ± 5.76 months (range, 12-30 months). RESULTS: Early postoperative evaluation showed a clear graft in all cases. A normal corneal pattern topography and a physiologic thickness (mean corneal pachymetry, 542.48 ± 33.20 μm) and transparency were restored. Twelve months after surgery, the mean postoperative uncorrected visual acuity was 0.45 ± 0.34 SD, and the mean best spectacle-corrected visual acuity was 0.63 ± 0.16 SD. CONCLUSIONS: Although the numbers in our study are small, our early results indicate that femtosecond laser-assisted lamellar keratoplasty shows promise as a safe and effective surgical choice in the treatment of various corneal pathologies.

Original languageEnglish
Pages (from-to)668-672
Number of pages5
JournalCornea
Volume27
Issue number6
DOIs
Publication statusPublished - Jul 2008

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Corneal Transplantation
Visual Acuity
Lasers
Corneal Pachymetry
Tissue Donors
Pathology
Corneal Topography
Corneal Opacity
Keratoconus
Confocal Microscopy
Cornea
Transplants
Safety
Therapeutics

Keywords

  • Corneal diseases
  • Femtosecond laser
  • Keratoconus
  • Lamellar keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mosca, L., Fasciani, R., Tamburelli, C., Buzzonetti, L., Guccione, L., Mandarà, E., & Balestrazzi, E. (2008). Femtosecond laser-assisted lamellar keratoplasty: Early results. Cornea, 27(6), 668-672. https://doi.org/10.1097/ICO.0b013e31816736b1

Femtosecond laser-assisted lamellar keratoplasty : Early results. / Mosca, Luigi; Fasciani, Romina; Tamburelli, Ciro; Buzzonetti, Luca; Guccione, Laura; Mandarà, Erika; Balestrazzi, Emilio.

In: Cornea, Vol. 27, No. 6, 07.2008, p. 668-672.

Research output: Contribution to journalArticle

Mosca, L, Fasciani, R, Tamburelli, C, Buzzonetti, L, Guccione, L, Mandarà, E & Balestrazzi, E 2008, 'Femtosecond laser-assisted lamellar keratoplasty: Early results', Cornea, vol. 27, no. 6, pp. 668-672. https://doi.org/10.1097/ICO.0b013e31816736b1
Mosca L, Fasciani R, Tamburelli C, Buzzonetti L, Guccione L, Mandarà E et al. Femtosecond laser-assisted lamellar keratoplasty: Early results. Cornea. 2008 Jul;27(6):668-672. https://doi.org/10.1097/ICO.0b013e31816736b1
Mosca, Luigi ; Fasciani, Romina ; Tamburelli, Ciro ; Buzzonetti, Luca ; Guccione, Laura ; Mandarà, Erika ; Balestrazzi, Emilio. / Femtosecond laser-assisted lamellar keratoplasty : Early results. In: Cornea. 2008 ; Vol. 27, No. 6. pp. 668-672.
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AB - PURPOSE: To evaluate the outcomes and safety of lamellar keratoplasty (LK) assisted by a femtosecond laser. METHODS: Twenty-one eyes of 21 patients affected by different corneal pathologies (5 posttraumatic corneal scar, 3 postkeratitis corneal leucoma, and 13 keratoconus) underwent LK procedures by using a femtosecond laser. The mean thinnest corneal thickness, evaluated with ultrasound corneal pachymetry and with confocal microscopy, was 434.19 ± 62.60 (SD) μm (range, 333-548 μm). Mean preoperative uncorrected visual acuity was 0.09 ± 0.28 SD and mean preoperative best spectacle-corrected visual acuity was 0.28 ± 0.15 SD. A femtosecond laser was used to perform corneal cuts on both donor and recipient corneas. The donor corneal lamella diameters were 0.20-mm larger and thicker than the recipient to restore a physiologic corneal thickness and shape: mean donor diameter was 8.34 ± 0.28 mm (range, 8.2-8.7 mm) and mean thickness was 352 ± 40.27 μm (range, 220-400 μm). Mean follow-up was 20.86 ± 5.76 months (range, 12-30 months). RESULTS: Early postoperative evaluation showed a clear graft in all cases. A normal corneal pattern topography and a physiologic thickness (mean corneal pachymetry, 542.48 ± 33.20 μm) and transparency were restored. Twelve months after surgery, the mean postoperative uncorrected visual acuity was 0.45 ± 0.34 SD, and the mean best spectacle-corrected visual acuity was 0.63 ± 0.16 SD. CONCLUSIONS: Although the numbers in our study are small, our early results indicate that femtosecond laser-assisted lamellar keratoplasty shows promise as a safe and effective surgical choice in the treatment of various corneal pathologies.

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