Fenoldopam in newborn patients undergoing cardiopulmonary bypass: Controlled clinical trial

Zaccaria Ricci, Giulia V. Stazi, Luca Di Chiara, Stefano Morelli, Vincenzo Vitale, Chiara Giorni, Claudio Ronco, Sergio Picardo

Research output: Contribution to journalArticle

Abstract

We determined if low dose fenoldopam in neonates already receiving conventional diuretics improves urine output, fluid balance, acute kidney injury incidence (AKI) and time to extubation. A prospective controlled clinical trial in a pediatric cardiac intensive care unit on 40 neonates undergoing cardiac surgery with cardiopulmonary bypass, excluding simple ventricular septal defect and atrial septal defect. Fenoldopam was infused at a low dose of 0.1 μg/kg/min soon after anesthesia induction and infusion prolonged for 72 h in 20 patients. Twenty neonates with standardized perioperative therapy except fenoldopam administration served as controls. Demographic, hemodynamic, daily urine output, creatinine, creatinine clearance, serum and urinary sodium and potassium were recorded. Inotropic score (IS) was calculated as a surrogate for the degree of hemodynamic impairment. Low dose fenoldopam infusion did not show beneficial effects in renal function. The treatment did not significantly affect IS value, AKI incidence, fluid balance control, time to sternal closure, time to extubation and time to intensive care unit discharge. Low dose fenoldopam in neonates undergoing cardiac surgery with CPB did not produce effects on urine output, fluid balance and AKI incidence. Fenoldopam was well tolerated and did not negatively affect hemodynamics and vasopressor support.

Original languageEnglish
Pages (from-to)1049-1053
Number of pages5
JournalInteractive Cardiovascular and Thoracic Surgery
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Acute kidney injury
  • Cardiopulmonary bypass
  • Congenital heart disease
  • Fenoldopam

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

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