Fentanyl pectin nasal spray as treatment for incident predictable breakthrough pain (BTP) in oral mucositis induced by chemoradiotherapy in head and neck cancer

Paolo Bossi, Laura Locati, Cristiana Bergamini, Aurora Mirabile, Roberta Granata, Martina Imbimbo, Carlo Resteghini, Lisa Licitra

Research output: Contribution to journalArticlepeer-review

Abstract

Background Painful mucositis is one of the most distressing toxicities of chemoradiotherapy (CRT) for head and neck cancer (HNC), with the characteristics of incidental predictable breakthrough pain (BTP) during swallowing. Fentanyl pectin nasal spray (FPNS) could be a good therapeutic option. Methods Patients were prospectively considered if receiving basal analgesic therapy with opiates for painful mucositis of grade ≥4 on a numerical rating scale from 0 to 10. They were offered FPNS 100 mcg before oral intake. When patients reached the effective dose, they evaluated the basal pain intensity before FPNS use and after 10, 20, 30 and 40 min. Results Seventeen HNC patients were offered FPNS before oral intake, with 15 patients completing treatment. Mean reduction of incidental BTP intensity after FPNS was 3.1 points (range 1.2-5.8). Mean time elapsed since FPNS use and highest pain reduction was 26 min. Conclusions FPNS demonstrated activity against BTP when swallowing in HNC patients. These data should be considered as hypothesis-generating.

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalOral Oncology
Volume50
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Breakthrough pain (BTP)
  • Chemo radiotherapy
  • Fentanyl pectin nasal spray
  • Head and neck cancer
  • Oral mucositis

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research
  • Medicine(all)

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