Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study

G. G. Giordano, A. M. Bevilacqua, M. V. Carriero

Research output: Contribution to journalArticle

Abstract

An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume3
Issue number3
Publication statusPublished - 1984

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Transferrin
Ferritins
Rectum
Colon
Carcinoma
Staining and Labeling
Histiocytes
Immunoenzyme Techniques
Mucous Membrane
Epithelial Cells
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study. / Giordano, G. G.; Bevilacqua, A. M.; Carriero, M. V.

In: Journal of Experimental and Clinical Cancer Research, Vol. 3, No. 3, 1984, p. 285-289.

Research output: Contribution to journalArticle

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