An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.
|Number of pages||5|
|Journal||Journal of Experimental and Clinical Cancer Research|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Cancer Research