Abstract
An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.
| Original language | English |
|---|---|
| Pages (from-to) | 285-289 |
| Number of pages | 5 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Giordano, G. G., Bevilacqua, A. M., & Carriero, M. V. (1984). Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study. Journal of Experimental and Clinical Cancer Research, 3(3), 285-289.