Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study

G. G. Giordano, A. M. Bevilacqua, M. V. Carriero

Research output: Contribution to journalArticlepeer-review


An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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