Abstract
An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.
| Original language | English |
|---|---|
| Pages (from-to) | 285-289 |
| Number of pages | 5 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study. / Giordano, G. G.; Bevilacqua, A. M.; Carriero, M. V.
In: Journal of Experimental and Clinical Cancer Research, Vol. 3, No. 3, 1984, p. 285-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ferritin and transferrin in colon-rectum carcinoma. An immunohistochemical study
AU - Giordano, G. G.
AU - Bevilacqua, A. M.
AU - Carriero, M. V.
PY - 1984
Y1 - 1984
N2 - An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.
AB - An immunoperoxidase staining technique was used for detecting the localization and distribution of ferritin and transferrin in 36 cases of colon-rectum carcinoma. The immunohistochemical findings mainly showed that: ferritin was prevalently localized in spindle-shaped cells or histiocytes of connectival stroma, surrounding neoplastic tissue; transferrin staining occurred in the epithelial cells of deep regions of transitional mucosa and in neoplastic cells of 11 carcinoma cases. These results might suggest that: hyperferritinaemia in malignancy is due to the so-called cytostromal reaction; transferrin positivities may occur only in normal and neoplastic cells with higher proliferative activity.
UR - http://www.scopus.com/inward/record.url?scp=0021637254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021637254&partnerID=8YFLogxK
M3 - Article
VL - 3
SP - 285
EP - 289
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 3
ER -