Ferritins in malignant and non-malignant lymphoid cells

P. Vezzoni, S. Levi, E. Gabri, M. R. Pozzi, S. Spinazze, P. Arosio

Research output: Contribution to journalArticle

Abstract

Lymphoid cells from peripheral blood, thymus, malignant and non-malignant lymph nodes were analysed for ferritin content using radioimmunoassays specific for the 'acidic' H-subunit-rich and for 'basic' L-subunit-rich isoferritins, and the data were compared with the immunological characteristics of the cells. All tissues with high proportion of T or 'null' cells contained the lowest concentration of L-subunit-rich isoferritins, while the H-subunit-rich forms increased from low levels in the quiescent peripheral blood lymphocytes (PBL), to higher values in the immature and proliferating thymocytes and lymphoblasts, malignant or not. B-cell lymphomas contained concentrations of both ferritin types higher than those found in PBL. No significant difference was found in the isoferritin concentrations between non-malignant lymph nodes and tissues involved in Hodgkin's disease. These findings indicate that maturation stage, proliferative status and anatomical localization affect isoferritin expression in lymphoid cells.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalBritish Journal of Haematology
Volume62
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Ferritins in malignant and non-malignant lymphoid cells'. Together they form a unique fingerprint.

  • Cite this

    Vezzoni, P., Levi, S., Gabri, E., Pozzi, M. R., Spinazze, S., & Arosio, P. (1986). Ferritins in malignant and non-malignant lymphoid cells. British Journal of Haematology, 62(1), 105-110.