Abstract
Hepatic siderosis is frequent in patients with Hepatitis C virus (HCV) chronic hepatitis and considered secondary to advanced liver disease when detected in the explanted liver of cirrhotic patients submitted to transplantation. Here, we document the early recurrence of hepatic iron overload starting from host Kupffer cells and later involving hepatocytes in an Italian male submitted to liver transplantation for HCV-related cirrhosis, whose hemosiderosis was interpreted as related to a primary defect of iron handling by monocytic cells due to decreased Ferroportin-1 expression. He was negative for HFE mutations, had normal liver function, did not drink alcohol and had no erythropoietic defect. He was positive for the (CGG)8/9 and the IVS1 -24 G > C Ferroportin-1 polymorphisms, associated with non-parenchymal iron overload, and had decreased Ferroportin-1 expression in monocytes. In conclusion, this case report documents the recurrence of progressive liver siderosis, which recalls Ferroportin disease, associated with decreased Ferroportin-1 expression in host monocytes repopulating the donor liver.
| Original language | English |
|---|---|
| Journal | Digestive and Liver Disease |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2009 |
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Keywords
- Cirrhosis
- Ferroportin-1
- Hepatitis C virus
- Iron overload
- Liver transplantation
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Ferroportin-1 in the recurrence of hepatic iron overload after liver transplantation. / Valenti, L.; Guido, M.; Dongiovanni, P.; Cremonesi, L.; Fracanzani, A. L.; Fargion, S.
In: Digestive and Liver Disease, Vol. 41, No. 7, 07.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ferroportin-1 in the recurrence of hepatic iron overload after liver transplantation
AU - Valenti, L.
AU - Guido, M.
AU - Dongiovanni, P.
AU - Cremonesi, L.
AU - Fracanzani, A. L.
AU - Fargion, S.
PY - 2009/7
Y1 - 2009/7
N2 - Hepatic siderosis is frequent in patients with Hepatitis C virus (HCV) chronic hepatitis and considered secondary to advanced liver disease when detected in the explanted liver of cirrhotic patients submitted to transplantation. Here, we document the early recurrence of hepatic iron overload starting from host Kupffer cells and later involving hepatocytes in an Italian male submitted to liver transplantation for HCV-related cirrhosis, whose hemosiderosis was interpreted as related to a primary defect of iron handling by monocytic cells due to decreased Ferroportin-1 expression. He was negative for HFE mutations, had normal liver function, did not drink alcohol and had no erythropoietic defect. He was positive for the (CGG)8/9 and the IVS1 -24 G > C Ferroportin-1 polymorphisms, associated with non-parenchymal iron overload, and had decreased Ferroportin-1 expression in monocytes. In conclusion, this case report documents the recurrence of progressive liver siderosis, which recalls Ferroportin disease, associated with decreased Ferroportin-1 expression in host monocytes repopulating the donor liver.
AB - Hepatic siderosis is frequent in patients with Hepatitis C virus (HCV) chronic hepatitis and considered secondary to advanced liver disease when detected in the explanted liver of cirrhotic patients submitted to transplantation. Here, we document the early recurrence of hepatic iron overload starting from host Kupffer cells and later involving hepatocytes in an Italian male submitted to liver transplantation for HCV-related cirrhosis, whose hemosiderosis was interpreted as related to a primary defect of iron handling by monocytic cells due to decreased Ferroportin-1 expression. He was negative for HFE mutations, had normal liver function, did not drink alcohol and had no erythropoietic defect. He was positive for the (CGG)8/9 and the IVS1 -24 G > C Ferroportin-1 polymorphisms, associated with non-parenchymal iron overload, and had decreased Ferroportin-1 expression in monocytes. In conclusion, this case report documents the recurrence of progressive liver siderosis, which recalls Ferroportin disease, associated with decreased Ferroportin-1 expression in host monocytes repopulating the donor liver.
KW - Cirrhosis
KW - Ferroportin-1
KW - Hepatitis C virus
KW - Iron overload
KW - Liver transplantation
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U2 - 10.1016/j.dld.2008.01.020
DO - 10.1016/j.dld.2008.01.020
M3 - Article
VL - 41
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 7
ER -