Abstract
Mesothelioma is a malignant tumor mainly correlated to occupational asbestos exposure. Rare reports describe its occurrence also in animals, mainly linked to asbestos in the environment. Asbestos exposure is demonstrated by the appearance of characteristic histological hallmarks: asbestos containing ferruginous bodies that are iron-based structures forming around fibers and also other dust particles. Here we present a clinical case of a suspect of mesothelioma in the peritoneum of a dog with parallel histological observation of ferruginous bodies. To possibly correlate the dog tumor to environmental exposure, we performed X-ray fluorescence (XRF) analyses at two different synchrotrons to resolve the ferruginous bodies’ composition. While the histological examination diagnoses a tubulo-papillary mesothelioma, the XRF analyses show that ferruginous bodies contain Si particles, resembling formations of exogenous origin; however, the morphology is unlikely that of asbestos fibers. We speculate that the peritoneal mesothelioma of this dog could be related to environmental exposure to non-asbestos material.
| Original language | English |
|---|---|
| Pages (from-to) | 35707-35714 |
| Number of pages | 8 |
| Journal | Environmental Science and Pollution Research |
| Volume | 25 |
| Issue number | 35 |
| DOIs | |
| Publication status | Published - Dec 1 2018 |
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Keywords
- Dog
- Ferruginous bodies
- Mesothelioma
- Silicon
- Synchrotron XRF microscopy
- X-ray microscopy
ASJC Scopus subject areas
- Environmental Chemistry
- Pollution
- Health, Toxicology and Mutagenesis
Cite this
Ferruginous bodies resolved by synchrotron XRF in a dog with peritoneal malignant mesothelioma. / Pascotto, Ernesto; Gianoncelli, Alessandra; Calligaro, Carla; Marcuzzo, Thomas; Melato, Mauro; Rizzardi, Clara; Pascolo, Lorella.
In: Environmental Science and Pollution Research, Vol. 25, No. 35, 01.12.2018, p. 35707-35714.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ferruginous bodies resolved by synchrotron XRF in a dog with peritoneal malignant mesothelioma
AU - Pascotto, Ernesto
AU - Gianoncelli, Alessandra
AU - Calligaro, Carla
AU - Marcuzzo, Thomas
AU - Melato, Mauro
AU - Rizzardi, Clara
AU - Pascolo, Lorella
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Mesothelioma is a malignant tumor mainly correlated to occupational asbestos exposure. Rare reports describe its occurrence also in animals, mainly linked to asbestos in the environment. Asbestos exposure is demonstrated by the appearance of characteristic histological hallmarks: asbestos containing ferruginous bodies that are iron-based structures forming around fibers and also other dust particles. Here we present a clinical case of a suspect of mesothelioma in the peritoneum of a dog with parallel histological observation of ferruginous bodies. To possibly correlate the dog tumor to environmental exposure, we performed X-ray fluorescence (XRF) analyses at two different synchrotrons to resolve the ferruginous bodies’ composition. While the histological examination diagnoses a tubulo-papillary mesothelioma, the XRF analyses show that ferruginous bodies contain Si particles, resembling formations of exogenous origin; however, the morphology is unlikely that of asbestos fibers. We speculate that the peritoneal mesothelioma of this dog could be related to environmental exposure to non-asbestos material.
AB - Mesothelioma is a malignant tumor mainly correlated to occupational asbestos exposure. Rare reports describe its occurrence also in animals, mainly linked to asbestos in the environment. Asbestos exposure is demonstrated by the appearance of characteristic histological hallmarks: asbestos containing ferruginous bodies that are iron-based structures forming around fibers and also other dust particles. Here we present a clinical case of a suspect of mesothelioma in the peritoneum of a dog with parallel histological observation of ferruginous bodies. To possibly correlate the dog tumor to environmental exposure, we performed X-ray fluorescence (XRF) analyses at two different synchrotrons to resolve the ferruginous bodies’ composition. While the histological examination diagnoses a tubulo-papillary mesothelioma, the XRF analyses show that ferruginous bodies contain Si particles, resembling formations of exogenous origin; however, the morphology is unlikely that of asbestos fibers. We speculate that the peritoneal mesothelioma of this dog could be related to environmental exposure to non-asbestos material.
KW - Dog
KW - Ferruginous bodies
KW - Mesothelioma
KW - Silicon
KW - Synchrotron XRF microscopy
KW - X-ray microscopy
UR - http://www.scopus.com/inward/record.url?scp=85055741162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055741162&partnerID=8YFLogxK
U2 - 10.1007/s11356-018-3521-x
DO - 10.1007/s11356-018-3521-x
M3 - Article
C2 - 30357666
AN - SCOPUS:85055741162
VL - 25
SP - 35707
EP - 35714
JO - Environmental Science and Pollution Research
JF - Environmental Science and Pollution Research
SN - 0944-1344
IS - 35
ER -