@article{17d02c2b741942999db31612e071172a,
title = "Fertility concerns, preservation strategies and quality of life in young women with breast cancer: Baseline results from an ongoing prospective cohort study in selected European Centers",
abstract = "Objectives: Most research addressing needs and concerns of young patients with breast cancer (≤40 years) is retrospective. The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns. Here we report the baseline data and focus on predictors of fertility concerns. Materials and methods: Patient surveys and medical record review were used. The baseline survey included sociodemographic, medical and treatment data as well as questions on fertility concerns and preservation strategies. Subscales from the CAncer Rehabilitation Evaluation System-Short Form (CARES-SF) were administered to measure specific quality of life aspects. Uni- and multivariable modeling were used to investigate predictors of greater fertility concern. Results: Among 297 eligible respondents, 67% discussed fertility issues before starting therapy, 64% were concerned about becoming infertile after treatment, and 15% decided not to follow prescribed therapies. Fifty-four percent of women wished future children before diagnosis; of these, 71% still desired biologic children afterwards. In multivariable analysis, not having children was the only patient characteristic significantly associated with fertility concerns at diagnosis. Twenty-seven percent used fertility preservation strategies. Women who received chemotherapy reported greater physical (p = 0.021) and sexual difficulties (p = 0.039) than women who did not. Women who were married or had a partner reported less psychosocial problems than single women (p = 0.039). Conclusions: Young women with newly diagnosed breast cancer have several concerns, including, but not limited to, fertility. The HOHO European study provides valuable information to develop targeted interventions. {\textcopyright} 2019 Elsevier Ltd",
keywords = "Breast cancer, Fertility concerns, Psychosocial aspects, Quality of life, Young women, adult, Article, breast cancer, cancer chemotherapy, cohort analysis, controlled study, demography, Europe, female, female fertility, fertility preservation, health survey, human, longitudinal study, major clinical study, married person, mastectomy, medical decision making, medical record review, molecularly targeted therapy, physical disease, prescription, priority journal, prospective study, quality of life, retrospective study, sexual dysfunction, age, breast tumor, clinical trial, comparative study, decision making, Italy, multicenter study, psychology, questionnaire, risk assessment, Switzerland, United States, Adult, Age Factors, Breast Neoplasms, Cohort Studies, Decision Making, Female, Fertility Preservation, Humans, Longitudinal Studies, Prospective Studies, Quality of Life, Risk Assessment, Surveys and Questionnaires",
author = "M. Ruggeri and E. Pagan and V. Bagnardi and N. Bianco and E. Gallerani and K. Buser and M. Giordano and L. Gianni and M. Rabaglio and A. Freschi and E. Cretella and M. Clerico and A. Farolfi and E. Simoncini and M. Ciccarese and D. Rauch and M. Ramello and A. Glaus and R. Berardi and A.F. Pellanda and K. Ribi and S. Gelber and A.H. Partridge and A. Goldhirsch and O. Pagani",
note = "Cited By :3 Export Date: 2 March 2020 CODEN: BREAE Correspondence Address: Ruggeri, M.; International Breast Cancer Study Group (IBCSG), Effingerstrasse 40, Switzerland; email: monica.ruggeri@ibcsg.org Funding details: Faculty of Science and Engineering, University of Manchester, FSE Funding details: European Southern Observatory, ESO Funding text 1: This work was supported by the Frontier Science & Technology Research Foundation, Southern Europe (FSE) , Chiasso, Switzerland and the International Breast Cancer Study Group (IBCSG) , Bern, Switzerland. Funding text 2: The IBCSG 43-09 HOHO European protocol was developed and conducted by the Frontier Science & Technology Research Foundation , Southern Europe (FSE) and the International Breast Cancer Study Group (IBCSG) with the financial support of the Fondazione Leonardo , Lugano Switzerland, Pink Ribbon Switzerland and private donations . We thank the patients, physicians, nurses and trial coordinators who participated in the HOHO Study. Appendix A References: DeSantis, C.E., Fedewa, S.A., Goding Sauer, A., Kramer, J.L., Smith, R.A., Jemal, A., Breast cancer statistics, 2015: convergence of incidence rates between black and white women (2016) CA A Cancer J Clin, 66 (1), pp. 31-42; De Angelis, R., Sant, M., Coleman, M.P., Francisci, S., Baili, P., Pierannunzio, D., Trama, A., Capocaccia, R., Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE—5-a population-based study (2014) Lancet Oncol, 15 (1), pp. 23-34; Assi, H.A., Khoury, K.E., Dbouk, H., Khalil, L.E., Mouhieddine, T.H., El Saghir, N.S., Epidemiology and prognosis of breast cancer in young women (2013) J Thorac Dis, 5, pp. S2-S8; Ruddy, K.J., Partridge, A.H., Fertility (male and female) and menopause (2012) J Clin Oncol, 30, pp. 3705-3711; Matthews, T.J., Hamilton, B.E., First births to older women continue to rise (2014) NCHS Data Brief, 152, pp. 1-8; Cooke, A., Mills, T.A., Lavender, T., Informed and uninformed decision making{\textquoteright}– women's reasoning, experiences and perceptions with regard to advanced maternal age and delayed childbearing: a meta-synthesis (2010) Int J Nurs Stud, 47, pp. 1317-1329; Northouse, L.L., Breast cancer in younger women: effects on interpersonal and family relations (1994) J Natl Cancer Inst Monogr, 16, pp. 183-190; Partridge, A.H., Cancer survivorship and the young breast cancer patient: addressing the important issues (2013) The Oncologist, 18 (8), pp. e19-e20; Campbell-Enns, H., Woodgate, R., The psychosocial experiences of women with breast cancer across the lifespan: a systematic review protocol (2015) JBI Database Syst Rev Implem Rep, 13 (1), pp. 112-121; Howard-Anderson, J., Ganz, P.A., Bower, J.E., Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review (2012) J Natl Cancer Inst, 104 (5), pp. 386-405; Letourneau, J.M., Ebbel, E.E., Katz, P.P., Katz, A., Ai, W.Z., Chien, A.J., Melisko, M.E., Rosen, M.P., Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer (2012) Cancer, 118 (6), pp. 1710-1717; McCray, D.K., Simpson, A.B., Flyckt, R., Liu, Y., O'Rourke, C., Crowe, J.P., Grobmyer, S.R., Valente, S.A., Fertility in women of reproductive age after breast cancer treatment: practice patterns and outcomes (2016) Ann Surg Oncol, 23 (10), pp. 3175-3181; Lambertini, M., Goldrat, O., Clatot, F., Demeestere, I., Awada, A., Controversies about fertility and pregnancy issues in young breast cancer patients: current state of the art (2017) Curr Opin Oncol, 29 (4), pp. 243-252; Ruddy, K.J., Gelber, S.I., Tamimi, R.M., Ginsburg, E.S., Schapira, L., Come, S.E., Borges, V.F., Partridge, A.H., Prospective study of fertility concerns and preservation strategies in young women with breast cancer (2014) J Clin Oncol, 32 (11), pp. 1151-1156; Pasick, R.J., Stewart, S.L., Bird, J.A., D'Onofrio, C.N., Quality of data in multiethnic health surveys (2001) Public Health Rep, 116, pp. 223-243. , 2001; Coscarelli Schag, C.A., Ganz, P.A., Heinrich, R.L., CAncer rehabilitation evaluation system–short form (CARES-SF). A cancer specific rehabilitation and quality of life instrument (1991) Cancer, 68 (6), pp. 1406-1413. , Sep. 15; Partridge, A.H., Gelber, S., Peppercorn, J., Sampson, E., Knudsen, K., Laufer, M., Rosenberg, R., Winer, E.P., Web-based survey of fertility issues in young women with breast cancer (2004) J Clin Oncol, 22 (20), pp. 4174-4183; Hsieh, F.Y., Bloch, D.A., Larsen, M.D., A simple method of sample size calculation for linear and logistic regression (1998) Stat Med, 17 (14), pp. 1623-1634; V Bagnardi, O.P., Ruggeri, M., Bianco, N., Gallerani, E., Buser, K., Giordano, M., Gianni, L., Colleoni, M., HOHO study: how European and US young women cope with breast cancer and fertility concerns. Poster PD6-04 (2016), San Antonio Breast Cancer Symposium December 6-10, 2016; Lambertini, M., Di Maio, M., Pagani, O., Curigliano, G., Poggio, F., Del Mastro, L., Paluch-Shimon, S., Peccatori, F.A., A survey on physicians' knowledge, practice and attitudes on fertility and pregnancy issues in young breast cancer patients (2018) Breast, 42, p. 41e49; Murphy, C.C., Bartholomew, L.K., Carpentier, M.Y., Bluethmann, S.M., Vernon, S.W., Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review (2012) Breast Canc Res Treat, 134 (2), pp. 459-478; Hershman, D.L., Kushi, L.H., Shao, T., Buono, D., Kershenbaum, A., Tsai, W.Y., Fehrenbacher, L., Neugut, A.I., Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients (2010) J Clin Oncol, 28 (27), pp. 4120-4128; Oktay, K., Harvey, B.E., Partridge, A.H., Quinn, G.P., Reinecke, J., Taylor, H.S., Wallace, W.H., Loren, A.W., Fertility preservation in patients with cancer: ASCO clinical practice guideline update (2018) J Clin Oncol, 36 (19), pp. 1994-2001; Selter, J., Huang, Y., Grossman Becht, L.C., Palmerola, K.L., Williams, S.Z., Forman, E., Ananth, C.V., Wright, J.D., Use of fertility preservation services in female reproductive-aged cancer patients (2019) Am J Obstet Gynecol, S0002–9378 (19). , 30667-2; Kim, J., Oktay, K., Gracia, C., Lee, S., Morse, C., Mersereau, J.E., Which patients pursue fertility preservation treatments? A multicenter analysis of the predictors of fertility preservation in women with breast cancer (2012) Fertil Steril, 97 (3), pp. 671-676; Altice, C.K., Banegas, M.P., Tucker-Seeley, R.D., Yabroff, K.R., Financial hardships experienced by cancer survivors: a systematic review (2017) JNCI J Natl Cancer Inst, 109 (2), p. djw205",
year = "2019",
doi = "10.1016/j.breast.2019.07.001",
language = "English",
volume = "47",
pages = "85--92",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
}