Fertility drugs, reproductive strategies and ovarian cancer risk

Federica Tomao, Giuseppe Lo Russo, Gian Paolo Spinelli, Valeria Stati, Alessandra Anna Prete, Natalie Prinzi, Marsela Sinjari, Patrizia Vici, Anselmo Papa, Maria Stefania Chiotti, Pierluigi Benedetti Panici, Silverio Tomao

Research output: Contribution to journalArticlepeer-review


Several adverse effects have been related to infertility treatments, such as cancer development. In particular, the relationship between infertility, reproductive strategies, and risk of gynecological cancers has aroused much interest in recent years. The evaluation of cancer risk among women treated for infertility is very complex, mainly because of many factors that can contribute to occurrence of cancer in these patients (including parity status). This article addresses the possible association between the use of fertility treatments and the risk of ovarian cancer, through a scrupulous search of the literature published thus far in this field. Our principal objective was to give more conclusive answers on the question whether the use of fertility drug significantly increases ovarian cancer risk. Our analysis focused on the different types of drugs and different treatment schedules used. This study provides additional insights regarding the long-term relationships between fertility drugs and risk of ovarian cancer.

Original languageEnglish
Article number51
JournalJournal of Ovarian Research
Issue number1
Publication statusPublished - May 8 2014


  • Clomiphene citrate
  • Fertility drugs
  • in vitro fertilization
  • Ovarian cancer
  • Ovarian stimulation

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology
  • Medicine(all)


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