Abstract
Purpose: To evaluate fertility in male patients with osteosarcoma after chemotherapy including high doses of alkylating agents. Patients and Methods: Postchemotherapy fertility was evaluated in 96 male patients who received chemotherapy at the authors' institution from 1976 to 1996 for localized bone osteosarcoma of the extremities. Four drugs were administrated (doxorubicin, cisplatin, methotrexate, ifosfamide) at different doses according to six different protocols. Eleven patients were prepubertal and 85 were postpubertal at the time of chemotherapy. The median age of these patients at the time of chemotherapy was 17 years (range 10-42), the median age at the time of the interview was 27 years (range 19-53), and the median follow-up from the end of chemotherapy was 9 years (range 4-17). Results: Of the 96 patients, 26 underwent sperm analysis and 20 showed oligo- or azoospermia. Patients who received high-dose ifosfamide showed a higher incidence of azoospermia. Six patients were normospermic and received no ifosfamide or lower doses of ifosfamide. Eight patients fathered a total of 12 children. No birth defects or congenital anomalies were observed in their offspring. Conclusions: The rate of sterility was related to ifosfamide dosage. It appears that pubertal maturation is not affected by chemotherapy. No congenital malformations were seen in the children of the few patients who fathered children.
| Original language | English |
|---|---|
| Pages (from-to) | 292-296 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Hematology/Oncology |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2003 |
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Keywords
- Chemotherapy
- High-dose alkylating agents
- Male fertility
- Osteosarcoma
- Pediatrics
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Hematology
Cite this
Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. / Longhi, Alessandra; Macchiagodena, Michele; Vitali, Giovanni; Bacci, Gaetano.
In: Journal of Pediatric Hematology/Oncology, Vol. 25, No. 4, 04.2003, p. 292-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma
AU - Longhi, Alessandra
AU - Macchiagodena, Michele
AU - Vitali, Giovanni
AU - Bacci, Gaetano
PY - 2003/4
Y1 - 2003/4
N2 - Purpose: To evaluate fertility in male patients with osteosarcoma after chemotherapy including high doses of alkylating agents. Patients and Methods: Postchemotherapy fertility was evaluated in 96 male patients who received chemotherapy at the authors' institution from 1976 to 1996 for localized bone osteosarcoma of the extremities. Four drugs were administrated (doxorubicin, cisplatin, methotrexate, ifosfamide) at different doses according to six different protocols. Eleven patients were prepubertal and 85 were postpubertal at the time of chemotherapy. The median age of these patients at the time of chemotherapy was 17 years (range 10-42), the median age at the time of the interview was 27 years (range 19-53), and the median follow-up from the end of chemotherapy was 9 years (range 4-17). Results: Of the 96 patients, 26 underwent sperm analysis and 20 showed oligo- or azoospermia. Patients who received high-dose ifosfamide showed a higher incidence of azoospermia. Six patients were normospermic and received no ifosfamide or lower doses of ifosfamide. Eight patients fathered a total of 12 children. No birth defects or congenital anomalies were observed in their offspring. Conclusions: The rate of sterility was related to ifosfamide dosage. It appears that pubertal maturation is not affected by chemotherapy. No congenital malformations were seen in the children of the few patients who fathered children.
AB - Purpose: To evaluate fertility in male patients with osteosarcoma after chemotherapy including high doses of alkylating agents. Patients and Methods: Postchemotherapy fertility was evaluated in 96 male patients who received chemotherapy at the authors' institution from 1976 to 1996 for localized bone osteosarcoma of the extremities. Four drugs were administrated (doxorubicin, cisplatin, methotrexate, ifosfamide) at different doses according to six different protocols. Eleven patients were prepubertal and 85 were postpubertal at the time of chemotherapy. The median age of these patients at the time of chemotherapy was 17 years (range 10-42), the median age at the time of the interview was 27 years (range 19-53), and the median follow-up from the end of chemotherapy was 9 years (range 4-17). Results: Of the 96 patients, 26 underwent sperm analysis and 20 showed oligo- or azoospermia. Patients who received high-dose ifosfamide showed a higher incidence of azoospermia. Six patients were normospermic and received no ifosfamide or lower doses of ifosfamide. Eight patients fathered a total of 12 children. No birth defects or congenital anomalies were observed in their offspring. Conclusions: The rate of sterility was related to ifosfamide dosage. It appears that pubertal maturation is not affected by chemotherapy. No congenital malformations were seen in the children of the few patients who fathered children.
KW - Chemotherapy
KW - High-dose alkylating agents
KW - Male fertility
KW - Osteosarcoma
KW - Pediatrics
UR - http://www.scopus.com/inward/record.url?scp=0242684432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242684432&partnerID=8YFLogxK
U2 - 10.1097/00043426-200304000-00005
DO - 10.1097/00043426-200304000-00005
M3 - Article
C2 - 12679642
AN - SCOPUS:0242684432
VL - 25
SP - 292
EP - 296
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 4
ER -