Fertility sparing surgery in early stage epithelial ovarian cancer

Antonino Ditto, Fabio Martinelli, Domenica Lorusso, Edward Haeusler, Marialuisa Carcangiu, Francesco Raspagliesi

Research output: Contribution to journalArticlepeer-review

Abstract

Methods: From January 2003 to January 2011, 24 patients underwent fertility sparing surgery. Eighteen were one-to-one matched and balanced for stage, histologic type and grading with a group of patients who underwent radical comprehensive staging (n=18). Demographics, surgical procedures, morbidities, pathologic findings, recurrence-rate, pregnancy-rate and correlations with disease-free survival were assessed.

Results: A total of 36 patients had a complete surgical staging including lymphadenectomy and were therefore analyzed. Seven patients experienced a recurrence: four (22%) in the fertility sparing surgery group and three (16%) in the control group (p=not significant). Sites of recurrence were: residual ovary (two), abdominal wall and peritoneal carcinomatosis in the fertility sparing surgery group; pelvic (two) and abdominal wall in the control group. Recurrences in the fertility sparing surgery group appeared earlier (mean, 10.3 months) than in radical comprehensive staging group (mean, 53.3 months) p

Conclusion: Fertility sparing surgery in early epithelial ovarian cancer submitted to a comprehensive surgical staging could be considered safe with oncological results comparable to radical surgery group.

Objective: Fertility sparing surgery (FSS) is a strategy often considered in young patients with early epithelial ovarian cancer. We investigated the role and the outcomes of FSS in eEOC patients who underwent comprehensive surgery.

Original languageEnglish
Pages (from-to)320-327
Number of pages8
JournalJournal of Gynecologic Oncology
Volume25
Issue number4
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Disease-free survival
  • Fertility
  • Lymph node excision
  • Neoplasm recurrence
  • Ovarian neoplasms
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)

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