Fertility-sparing treatment in young women with endometrial cancer or atypical complex hyperplasia: A prospective single-institution experience of 21 cases

M. Signorelli, G. Caspani, C. Bonazzi, V. Chiappa, P. Perego, C. Mangioni

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a prospective study of conservative treatment in 21 young nulliparous women with grade (G)1 endometrial cancer stage IA (11) or atypical complex hyperplasia (10). All were treated with a low-dose cyclic natural progestin therapy (200 mg/day from day 14-25) and encouraged to attempt pregnancy immediately. No adverse therapy-related effects were recorded. Overall response rate to progestin therapy was 57%. Nine women conceived (43%). There were 13 pregnancies, of which 13 were spontaneous and 8 were in women with persistent disease or partial response to hormonal treatment. Three additional complete responses were observed after delivery. Only women with known primary infertility or severe polycystic ovary syndrome showed inadequate pregnancy rate. Fifteen women underwent definitive surgery after enrolment (median 27 months, range 3-56 months). All 21 women are alive and disease free after a median follow up of 98 months.

Original languageEnglish
Pages (from-to)114-118
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume116
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Atypical complex hyperplasia
  • Childbearing age
  • Conservative management
  • Endometrial cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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