Fertility treatment and risk of breast cancer

Claudia Braga, Eva Negri, Carlo La Vecchia, Fabio Parazzini, Luigino Dal Maso, Silvia Franceschi

Research output: Contribution to journalArticlepeer-review


The relationship between fertility treatment and breast cancer was investigated in a multicentric case-control study conducted in Italy on 2569 women with incident, histologically confirmed breast cancer and 2588 control women admitted to hospitals for acute, non-neoplastic, non-hormonal or gynaecological conditions, unrelated to fertility problems. The odds ratio of breast cancer was 1.08 (95% confidence interval 0.8-1.5) in those reporting fertility treatment compared with those who did not receive fertility treatment. Similarly, the odds ratio was 0.60 for women with tubal occlusion, 0.99 for those reporting hormonal imbalances and 1.32 for other/unspecified reasons. There was no consistent pattern of risk according to age at treatment and time since treatment. Women reporting fertility treatment with drug use had an odds ratio of 1.43, while those who did not report drug therapy had an odds ratio of 0.85. None of these odds ratio estimates was significant. Likewise, there was no heterogeneity among strata of parity, menopausal status, education and family history of breast cancer, Thus, our study, while providing reassuring evidence; on the relationship between fertility treatment and breast cancer risk, cannot exclude the possibility that the use of specific drugs may be related to breast carcinogenesis.

Original languageEnglish
Pages (from-to)300-303
Number of pages4
JournalHuman Reproduction
Issue number2
Publication statusPublished - Feb 1996


  • Breast cancer
  • Fertility drugs

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine


Dive into the research topics of 'Fertility treatment and risk of breast cancer'. Together they form a unique fingerprint.

Cite this