Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: A single-center experience

M. A. Rustico, M. M. Lanna, S. Faiola, V. Schena, M. Dell'Avanzo, V. Mantegazza, C. Parazzini, G. Lista, B. Scelsa, D. Consonni, E. Ferrazzi

Research output: Contribution to journalArticle

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Abstract

Objective: To report the incidence of fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome (TTTS). Methods: A total of 150 cases of TTTS were treated from January 2004 to June 2009 (period 1, 2004-2006, 62 cases; period 2, 2007 to June 2009, 88 cases). Fetal complications (double and single intrauterine fetal death, recurrence of TTTS, twin anemia-polycythemia sequence (TAPS), reversal of TTTS, cerebral lesions in one twin) and maternal complications were recorded, and retrospectively analyzed. Results: Nineteen (12.6%), 58 (38.7%), 61 (40.7%) and 12 cases (8.0%) were classified preoperatively as Quintero stage I, II, III and IV, respectively. The anterior placenta was described in 73 cases (48.6%). Double and single fetal death occurred overall in 7.3 and 36.0% of cases, respectively. The rate of recurrence was 11.3%, of TAPS 3.3%, and of reversal of TTTS 1.3%. Cerebral lesions were diagnosed in 3 donors (2.0%). Eighteen cases (12.0%) of fetal complications had a second procedure (6 repeat laser, 4 serial amnioreduction, 8 bipolar cord coagulation). Pregnancies undergoing a second procedure delivered at a median gestational age of 30.2 weeks compared to 32.1 weeks for those not repeating (p = 0.04). Perinatal survival of at least one twin improved from 66.1 to 79.5% (p = 0.06) in the two consecutive periods. For every 10 laser surgeries performed, there was an average improvement of 1.5% in the predicted percentage of survival of at least one twin (OR 1.09, 95% CI 1.00-1.19). Major maternal complications occurred in 9 cases (6.0%), 3 of which required admission to intensive care unit. Conclusions: Fetal complications are common after fetoscopic laser surgery. In this experience, an increasing number of procedures improved the performance of a new fetoscopic laser center.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalFetal Diagnosis and Therapy
Volume31
Issue number3
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Fetoscopy
Fetofetal Transfusion
Laser Therapy
Mothers
Polycythemia
Fetal Death
Anemia
Lasers
Recurrence
Placenta
Gestational Age
Intensive Care Units
Pregnancy
Incidence

Keywords

  • Fetal complications
  • Fetoscopic laser surgery
  • Maternal complications
  • Monochorionic pregnancy
  • Twin-to-twin transfusion syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging

Cite this

Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome : A single-center experience. / Rustico, M. A.; Lanna, M. M.; Faiola, S.; Schena, V.; Dell'Avanzo, M.; Mantegazza, V.; Parazzini, C.; Lista, G.; Scelsa, B.; Consonni, D.; Ferrazzi, E.

In: Fetal Diagnosis and Therapy, Vol. 31, No. 3, 04.2012, p. 170-178.

Research output: Contribution to journalArticle

Rustico, MA, Lanna, MM, Faiola, S, Schena, V, Dell'Avanzo, M, Mantegazza, V, Parazzini, C, Lista, G, Scelsa, B, Consonni, D & Ferrazzi, E 2012, 'Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: A single-center experience', Fetal Diagnosis and Therapy, vol. 31, no. 3, pp. 170-178. https://doi.org/10.1159/000336227
Rustico, M. A. ; Lanna, M. M. ; Faiola, S. ; Schena, V. ; Dell'Avanzo, M. ; Mantegazza, V. ; Parazzini, C. ; Lista, G. ; Scelsa, B. ; Consonni, D. ; Ferrazzi, E. / Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome : A single-center experience. In: Fetal Diagnosis and Therapy. 2012 ; Vol. 31, No. 3. pp. 170-178.
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AU - Lanna, M. M.

AU - Faiola, S.

AU - Schena, V.

AU - Dell'Avanzo, M.

AU - Mantegazza, V.

AU - Parazzini, C.

AU - Lista, G.

AU - Scelsa, B.

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AU - Ferrazzi, E.

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N2 - Objective: To report the incidence of fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome (TTTS). Methods: A total of 150 cases of TTTS were treated from January 2004 to June 2009 (period 1, 2004-2006, 62 cases; period 2, 2007 to June 2009, 88 cases). Fetal complications (double and single intrauterine fetal death, recurrence of TTTS, twin anemia-polycythemia sequence (TAPS), reversal of TTTS, cerebral lesions in one twin) and maternal complications were recorded, and retrospectively analyzed. Results: Nineteen (12.6%), 58 (38.7%), 61 (40.7%) and 12 cases (8.0%) were classified preoperatively as Quintero stage I, II, III and IV, respectively. The anterior placenta was described in 73 cases (48.6%). Double and single fetal death occurred overall in 7.3 and 36.0% of cases, respectively. The rate of recurrence was 11.3%, of TAPS 3.3%, and of reversal of TTTS 1.3%. Cerebral lesions were diagnosed in 3 donors (2.0%). Eighteen cases (12.0%) of fetal complications had a second procedure (6 repeat laser, 4 serial amnioreduction, 8 bipolar cord coagulation). Pregnancies undergoing a second procedure delivered at a median gestational age of 30.2 weeks compared to 32.1 weeks for those not repeating (p = 0.04). Perinatal survival of at least one twin improved from 66.1 to 79.5% (p = 0.06) in the two consecutive periods. For every 10 laser surgeries performed, there was an average improvement of 1.5% in the predicted percentage of survival of at least one twin (OR 1.09, 95% CI 1.00-1.19). Major maternal complications occurred in 9 cases (6.0%), 3 of which required admission to intensive care unit. Conclusions: Fetal complications are common after fetoscopic laser surgery. In this experience, an increasing number of procedures improved the performance of a new fetoscopic laser center.

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