Fetal and obstetric manifestations in the antiphospholipid syndrome

Angela Tincani, Monica Nuzzo, Andrea Lojacono, Maria Gerosa, Pierluigi Meroni

Research output: Contribution to journalArticle

Abstract

Antiphospholipid syndrome (APS) in pregnancy is characterized by the presence of autoantibodies in association with recurrent early miscarriages, fetal losses or severe obstetric complications such as prematurity, intrauterine growth restriction and uteroplacental insufficiency. Several mechanisms are hypothesized to explain the pathogenesis of pregnancy failures including decidual thrombosis or placental vasculopathy and antiphospholipid antibodies (aPL) direct effect on the utero-placental unit. According to the Sapporo criteria, APS is present in patients with three or more unexplained consecutive spontaneous abortions before the 10 th week of gestation, after exclusion of maternal anatomic or hormonal abnormalities, or one or more losses starting in the fetal period (from 10 th week of gestation). In the last years, several studies were performed for identifying the predictors of pregnancy outcome in APS patients. The uterine artery Doppler is a useful method for the study of patients at higher risk of preeclampsia and small for gestational age infants. A multidisciplinary team (obstetricians, rheumatologists and neonatologists) is important to achieve a good obstetric outcome and to reduce the possible consequences of premature delivery.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalCurrent Rheumatology Reviews
Volume6
Issue number1
Publication statusPublished - Feb 2010

Fingerprint

Antiphospholipid Syndrome
Obstetrics
Pregnancy
Small for Gestational Age Infant
Habitual Abortion
Uterine Artery
Antiphospholipid Antibodies
Spontaneous Abortion
Pregnancy Outcome
Pre-Eclampsia
Autoantibodies
Thrombosis
Mothers
Growth

Keywords

  • Antiphospholipid antibodies
  • Antiphospholipid syndrome
  • Early miscarriages
  • Fetal loss
  • HELLP syndrome
  • Preeclampsia

ASJC Scopus subject areas

  • Rheumatology

Cite this

Tincani, A., Nuzzo, M., Lojacono, A., Gerosa, M., & Meroni, P. (2010). Fetal and obstetric manifestations in the antiphospholipid syndrome. Current Rheumatology Reviews, 6(1), 18-24.

Fetal and obstetric manifestations in the antiphospholipid syndrome. / Tincani, Angela; Nuzzo, Monica; Lojacono, Andrea; Gerosa, Maria; Meroni, Pierluigi.

In: Current Rheumatology Reviews, Vol. 6, No. 1, 02.2010, p. 18-24.

Research output: Contribution to journalArticle

Tincani, A, Nuzzo, M, Lojacono, A, Gerosa, M & Meroni, P 2010, 'Fetal and obstetric manifestations in the antiphospholipid syndrome', Current Rheumatology Reviews, vol. 6, no. 1, pp. 18-24.
Tincani, Angela ; Nuzzo, Monica ; Lojacono, Andrea ; Gerosa, Maria ; Meroni, Pierluigi. / Fetal and obstetric manifestations in the antiphospholipid syndrome. In: Current Rheumatology Reviews. 2010 ; Vol. 6, No. 1. pp. 18-24.
@article{679ae8e95cd440bbb390947b804a4309,
title = "Fetal and obstetric manifestations in the antiphospholipid syndrome",
abstract = "Antiphospholipid syndrome (APS) in pregnancy is characterized by the presence of autoantibodies in association with recurrent early miscarriages, fetal losses or severe obstetric complications such as prematurity, intrauterine growth restriction and uteroplacental insufficiency. Several mechanisms are hypothesized to explain the pathogenesis of pregnancy failures including decidual thrombosis or placental vasculopathy and antiphospholipid antibodies (aPL) direct effect on the utero-placental unit. According to the Sapporo criteria, APS is present in patients with three or more unexplained consecutive spontaneous abortions before the 10 th week of gestation, after exclusion of maternal anatomic or hormonal abnormalities, or one or more losses starting in the fetal period (from 10 th week of gestation). In the last years, several studies were performed for identifying the predictors of pregnancy outcome in APS patients. The uterine artery Doppler is a useful method for the study of patients at higher risk of preeclampsia and small for gestational age infants. A multidisciplinary team (obstetricians, rheumatologists and neonatologists) is important to achieve a good obstetric outcome and to reduce the possible consequences of premature delivery.",
keywords = "Antiphospholipid antibodies, Antiphospholipid syndrome, Early miscarriages, Fetal loss, HELLP syndrome, Preeclampsia",
author = "Angela Tincani and Monica Nuzzo and Andrea Lojacono and Maria Gerosa and Pierluigi Meroni",
year = "2010",
month = "2",
language = "English",
volume = "6",
pages = "18--24",
journal = "Current Rheumatology Reviews",
issn = "1573-3971",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Fetal and obstetric manifestations in the antiphospholipid syndrome

AU - Tincani, Angela

AU - Nuzzo, Monica

AU - Lojacono, Andrea

AU - Gerosa, Maria

AU - Meroni, Pierluigi

PY - 2010/2

Y1 - 2010/2

N2 - Antiphospholipid syndrome (APS) in pregnancy is characterized by the presence of autoantibodies in association with recurrent early miscarriages, fetal losses or severe obstetric complications such as prematurity, intrauterine growth restriction and uteroplacental insufficiency. Several mechanisms are hypothesized to explain the pathogenesis of pregnancy failures including decidual thrombosis or placental vasculopathy and antiphospholipid antibodies (aPL) direct effect on the utero-placental unit. According to the Sapporo criteria, APS is present in patients with three or more unexplained consecutive spontaneous abortions before the 10 th week of gestation, after exclusion of maternal anatomic or hormonal abnormalities, or one or more losses starting in the fetal period (from 10 th week of gestation). In the last years, several studies were performed for identifying the predictors of pregnancy outcome in APS patients. The uterine artery Doppler is a useful method for the study of patients at higher risk of preeclampsia and small for gestational age infants. A multidisciplinary team (obstetricians, rheumatologists and neonatologists) is important to achieve a good obstetric outcome and to reduce the possible consequences of premature delivery.

AB - Antiphospholipid syndrome (APS) in pregnancy is characterized by the presence of autoantibodies in association with recurrent early miscarriages, fetal losses or severe obstetric complications such as prematurity, intrauterine growth restriction and uteroplacental insufficiency. Several mechanisms are hypothesized to explain the pathogenesis of pregnancy failures including decidual thrombosis or placental vasculopathy and antiphospholipid antibodies (aPL) direct effect on the utero-placental unit. According to the Sapporo criteria, APS is present in patients with three or more unexplained consecutive spontaneous abortions before the 10 th week of gestation, after exclusion of maternal anatomic or hormonal abnormalities, or one or more losses starting in the fetal period (from 10 th week of gestation). In the last years, several studies were performed for identifying the predictors of pregnancy outcome in APS patients. The uterine artery Doppler is a useful method for the study of patients at higher risk of preeclampsia and small for gestational age infants. A multidisciplinary team (obstetricians, rheumatologists and neonatologists) is important to achieve a good obstetric outcome and to reduce the possible consequences of premature delivery.

KW - Antiphospholipid antibodies

KW - Antiphospholipid syndrome

KW - Early miscarriages

KW - Fetal loss

KW - HELLP syndrome

KW - Preeclampsia

UR - http://www.scopus.com/inward/record.url?scp=77950261963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950261963&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77950261963

VL - 6

SP - 18

EP - 24

JO - Current Rheumatology Reviews

JF - Current Rheumatology Reviews

SN - 1573-3971

IS - 1

ER -