Fetal chondral homografts in the repair of articular cartilage defects

Nicola Specchia, Antonio Gigante, Francesco Falciglia, Francesco Greco

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalBulletin: Hospital for Joint Diseases
Volume54
Issue number4
Publication statusPublished - 1996

Fingerprint

Cartilage
Articular Cartilage
Grafts
Allografts
Repair
Transplants
Defects
Mechanical stability
Joints
Tissue
Patella
Wounds and Injuries
Chondrocytes
Thigh
Osteogenesis
Animals
Fetus
Acoustic waves
Rabbits
Bone and Bones

Keywords

  • animal study
  • cartilage, articular
  • homograft

ASJC Scopus subject areas

  • Rheumatology
  • Surgery
  • Bioengineering

Cite this

Fetal chondral homografts in the repair of articular cartilage defects. / Specchia, Nicola; Gigante, Antonio; Falciglia, Francesco; Greco, Francesco.

In: Bulletin: Hospital for Joint Diseases, Vol. 54, No. 4, 1996, p. 230-235.

Research output: Contribution to journalArticle

Specchia, Nicola ; Gigante, Antonio ; Falciglia, Francesco ; Greco, Francesco. / Fetal chondral homografts in the repair of articular cartilage defects. In: Bulletin: Hospital for Joint Diseases. 1996 ; Vol. 54, No. 4. pp. 230-235.
@article{22a3609b3a5742b396b7bc911bdc9b49,
title = "Fetal chondral homografts in the repair of articular cartilage defects",
abstract = "Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.",
keywords = "animal study, cartilage, articular, homograft",
author = "Nicola Specchia and Antonio Gigante and Francesco Falciglia and Francesco Greco",
year = "1996",
language = "English",
volume = "54",
pages = "230--235",
journal = "Bulletin of the NYU hospital for joint diseases",
issn = "0018-5647",
publisher = "Hospital For Joint Diseases Orthopaedic Institute",
number = "4",

}

TY - JOUR

T1 - Fetal chondral homografts in the repair of articular cartilage defects

AU - Specchia, Nicola

AU - Gigante, Antonio

AU - Falciglia, Francesco

AU - Greco, Francesco

PY - 1996

Y1 - 1996

N2 - Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.

AB - Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.

KW - animal study

KW - cartilage, articular

KW - homograft

UR - http://www.scopus.com/inward/record.url?scp=0029918461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029918461&partnerID=8YFLogxK

M3 - Article

C2 - 8731416

AN - SCOPUS:0029918461

VL - 54

SP - 230

EP - 235

JO - Bulletin of the NYU hospital for joint diseases

JF - Bulletin of the NYU hospital for joint diseases

SN - 0018-5647

IS - 4

ER -