Abstract
Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.
| Original language | English |
|---|---|
| Pages (from-to) | 230-235 |
| Number of pages | 6 |
| Journal | Bulletin: Hospital for Joint Diseases |
| Volume | 54 |
| Issue number | 4 |
| Publication status | Published - 1996 |
Fingerprint
Keywords
- animal study
- cartilage, articular
- homograft
ASJC Scopus subject areas
- Rheumatology
- Surgery
- Bioengineering
Cite this
Fetal chondral homografts in the repair of articular cartilage defects. / Specchia, Nicola; Gigante, Antonio; Falciglia, Francesco; Greco, Francesco.
In: Bulletin: Hospital for Joint Diseases, Vol. 54, No. 4, 1996, p. 230-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fetal chondral homografts in the repair of articular cartilage defects
AU - Specchia, Nicola
AU - Gigante, Antonio
AU - Falciglia, Francesco
AU - Greco, Francesco
PY - 1996
Y1 - 1996
N2 - Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.
AB - Lesions of the articular cartilage were bilaterally induced in the patella and the femoral condyle of adult NZW rabbits. A fresh fetal chondral homograft was implanted in one side, the untreated side serving as control. Fetal chondral tissue appeared to survive when implanted at the site of articular injury in adult animals, with no histological evidence of cell- mediated immune response. Fetal chondroblasts showed some signs of maturation and induced endochondral ossification at the base of the graft, with sound anchoring of the graft to the host tissue. In most cases, the homograft fused directly with the adjacent articular cartilage restoring the continuity of the articular surface. However, at implantation the graft could not be easily kept in place, and therefore some grafts had poor mechanical stability. Condylar grafts were incorporated better than patellar grafts. The healing process seemed to be related to be mechanical stability of the graft and to the anatomical site of injury.
KW - animal study
KW - cartilage, articular
KW - homograft
UR - http://www.scopus.com/inward/record.url?scp=0029918461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029918461&partnerID=8YFLogxK
M3 - Article
C2 - 8731416
AN - SCOPUS:0029918461
VL - 54
SP - 230
EP - 235
JO - Bulletin of the NYU hospital for joint diseases
JF - Bulletin of the NYU hospital for joint diseases
SN - 0018-5647
IS - 4
ER -