Abstract
Objective: To investigate sequential Doppler changes in donors and recipients before and 1 week after endoscopic laser for twin-to-twin transfusion syndrome (TTTS) and to examine factors that may be associated with such changes. Methods: In TTTS pregnancies undergoing laser treatment, we examined fetal Doppler changes before and 1 week postintervention. Intrauterine death rates and preoperative factors were analyzed in relation to Doppler changes. Results: Among 129 (85.4%) donors surviving at 1 week after laser, there was normalization of umbilical artery flow in 26 (72.2%) of 36 cases with preoperative abnormal Dopplers. In the remaining 10 (27.8%) fetuses, abnormal findings persisted. The rate of later intrauterine death was significantly higher in the latter group (6 of 10, 60.0%) compared with fetuses in which Doppler findings normalized (4 of 26, 15.4%; P < .05), with no difference in the rate of severe donor growth restriction between the 2 groups (80.0% vs 65.4%, respectively; P = .688). Conclusions: In about 70% of TTTS donors with preoperative abnormal umbilical artery Doppler, there was normalization 1 week after endoscopic laser. The incidence of fetal growth restriction was not significantly different in donors with persistence of Doppler abnormalities compared with those with normalized findings.
| Original language | English |
|---|---|
| Pages (from-to) | 344-348 |
| Journal | Prenatal Diagnosis |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 |
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ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Genetics(clinical)
Cite this
Fetal Doppler changes 1 week after endoscopic equatorial laser for twin-to-twin transfusion syndrome : A longitudinal study. / Persico, Nicola; D'Ambrosi, Francesco; Fabietti, Isabella; Boito, Simona; Aiello, Elisa; Bulfoni, Alessandro; Ciralli, Fabrizio; Kustermann, Alessandra; Mosca, Fabio; Fedele, Luigi.
In: Prenatal Diagnosis, Vol. 38, No. 5, 2018, p. 344-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fetal Doppler changes 1 week after endoscopic equatorial laser for twin-to-twin transfusion syndrome
T2 - A longitudinal study
AU - Persico, Nicola
AU - D'Ambrosi, Francesco
AU - Fabietti, Isabella
AU - Boito, Simona
AU - Aiello, Elisa
AU - Bulfoni, Alessandro
AU - Ciralli, Fabrizio
AU - Kustermann, Alessandra
AU - Mosca, Fabio
AU - Fedele, Luigi
PY - 2018
Y1 - 2018
N2 - Objective: To investigate sequential Doppler changes in donors and recipients before and 1 week after endoscopic laser for twin-to-twin transfusion syndrome (TTTS) and to examine factors that may be associated with such changes. Methods: In TTTS pregnancies undergoing laser treatment, we examined fetal Doppler changes before and 1 week postintervention. Intrauterine death rates and preoperative factors were analyzed in relation to Doppler changes. Results: Among 129 (85.4%) donors surviving at 1 week after laser, there was normalization of umbilical artery flow in 26 (72.2%) of 36 cases with preoperative abnormal Dopplers. In the remaining 10 (27.8%) fetuses, abnormal findings persisted. The rate of later intrauterine death was significantly higher in the latter group (6 of 10, 60.0%) compared with fetuses in which Doppler findings normalized (4 of 26, 15.4%; P < .05), with no difference in the rate of severe donor growth restriction between the 2 groups (80.0% vs 65.4%, respectively; P = .688). Conclusions: In about 70% of TTTS donors with preoperative abnormal umbilical artery Doppler, there was normalization 1 week after endoscopic laser. The incidence of fetal growth restriction was not significantly different in donors with persistence of Doppler abnormalities compared with those with normalized findings.
AB - Objective: To investigate sequential Doppler changes in donors and recipients before and 1 week after endoscopic laser for twin-to-twin transfusion syndrome (TTTS) and to examine factors that may be associated with such changes. Methods: In TTTS pregnancies undergoing laser treatment, we examined fetal Doppler changes before and 1 week postintervention. Intrauterine death rates and preoperative factors were analyzed in relation to Doppler changes. Results: Among 129 (85.4%) donors surviving at 1 week after laser, there was normalization of umbilical artery flow in 26 (72.2%) of 36 cases with preoperative abnormal Dopplers. In the remaining 10 (27.8%) fetuses, abnormal findings persisted. The rate of later intrauterine death was significantly higher in the latter group (6 of 10, 60.0%) compared with fetuses in which Doppler findings normalized (4 of 26, 15.4%; P < .05), with no difference in the rate of severe donor growth restriction between the 2 groups (80.0% vs 65.4%, respectively; P = .688). Conclusions: In about 70% of TTTS donors with preoperative abnormal umbilical artery Doppler, there was normalization 1 week after endoscopic laser. The incidence of fetal growth restriction was not significantly different in donors with persistence of Doppler abnormalities compared with those with normalized findings.
UR - http://www.scopus.com/inward/record.url?scp=85042541014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042541014&partnerID=8YFLogxK
U2 - 10.1002/pd.5234
DO - 10.1002/pd.5234
M3 - Article
AN - SCOPUS:85042541014
VL - 38
SP - 344
EP - 348
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 5
ER -