Abstract
1841 pregnant women without any risk factor for heart malformation of the fetus underwent an echocardiographic screening at an average gestational age of 23 weeks. Seven cases of heart diseases were diagnosed (0.38%), of which one died in utero at 28 weeks and another one was interrupted. In four cases the karyotype was carried out prenatally, while in the remaining three it was performed only after birth. There were 11 false-negative (0.59%), mainly concerning anomalies of minor clinical significance. Within this group, two newborns with interatrial defect of the ostium secundum type appeared to be affected by trisomy 21. Therefore, the rate of congenital heart diseases in live births not at risk (0.86%) was in line with the data reported in paediatric literature. On the other hand, the association with chromosomal anomalies was surprisingly frequent (4 out of the 9 karyotypes performed were anomalous). Such finding should be verified by studying a larger non-selected population. However, a fetal karyotype should be offered, for its practical consequences, also in those cases of cardiac anomalies of lesser clinical significance.
| Original language | English |
|---|---|
| Pages (from-to) | 19-25 |
| Number of pages | 7 |
| Journal | European Journal of Obstetrics and Gynecology and Reproductive Biology |
| Volume | 36 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 1990 |
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Keywords
- Fetal echocardiography
- Karyotype
- Screening
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Fetal echocardiography : the role of the screening procedure. / Rustico, M. A.; Benettoni, A.; D'Ottavio, G.; Bogatti, P.; Fontana, A.; Pecile, V.; Mandruzzato, G. P.
In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 36, No. 1-2, 1990, p. 19-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fetal echocardiography
T2 - the role of the screening procedure
AU - Rustico, M. A.
AU - Benettoni, A.
AU - D'Ottavio, G.
AU - Bogatti, P.
AU - Fontana, A.
AU - Pecile, V.
AU - Mandruzzato, G. P.
PY - 1990
Y1 - 1990
N2 - 1841 pregnant women without any risk factor for heart malformation of the fetus underwent an echocardiographic screening at an average gestational age of 23 weeks. Seven cases of heart diseases were diagnosed (0.38%), of which one died in utero at 28 weeks and another one was interrupted. In four cases the karyotype was carried out prenatally, while in the remaining three it was performed only after birth. There were 11 false-negative (0.59%), mainly concerning anomalies of minor clinical significance. Within this group, two newborns with interatrial defect of the ostium secundum type appeared to be affected by trisomy 21. Therefore, the rate of congenital heart diseases in live births not at risk (0.86%) was in line with the data reported in paediatric literature. On the other hand, the association with chromosomal anomalies was surprisingly frequent (4 out of the 9 karyotypes performed were anomalous). Such finding should be verified by studying a larger non-selected population. However, a fetal karyotype should be offered, for its practical consequences, also in those cases of cardiac anomalies of lesser clinical significance.
AB - 1841 pregnant women without any risk factor for heart malformation of the fetus underwent an echocardiographic screening at an average gestational age of 23 weeks. Seven cases of heart diseases were diagnosed (0.38%), of which one died in utero at 28 weeks and another one was interrupted. In four cases the karyotype was carried out prenatally, while in the remaining three it was performed only after birth. There were 11 false-negative (0.59%), mainly concerning anomalies of minor clinical significance. Within this group, two newborns with interatrial defect of the ostium secundum type appeared to be affected by trisomy 21. Therefore, the rate of congenital heart diseases in live births not at risk (0.86%) was in line with the data reported in paediatric literature. On the other hand, the association with chromosomal anomalies was surprisingly frequent (4 out of the 9 karyotypes performed were anomalous). Such finding should be verified by studying a larger non-selected population. However, a fetal karyotype should be offered, for its practical consequences, also in those cases of cardiac anomalies of lesser clinical significance.
KW - Fetal echocardiography
KW - Karyotype
KW - Screening
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U2 - 10.1016/0028-2243(90)90045-3
DO - 10.1016/0028-2243(90)90045-3
M3 - Article
C2 - 2365125
AN - SCOPUS:0025355458
VL - 36
SP - 19
EP - 25
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 1-2
ER -