Fetal growth patterns in Beckwith–Wiedemann syndrome

Alessandro Mussa, Silvia Russo, Agostina De Crescenzo, Andrea Freschi, Luciano Calzari, Silvia Maitz, Marina Macchiaiolo, Cristina Molinatto, Giuseppina Baldassarre, Milena Mariani, Luigi Tarani, Maria Francesca Bedeschi, Donatella Milani, Daniela Melis, Andrea Bartuli, M. Vittoria Cubellis, Angelo Selicorni, M. C. Silengo, Lidia Larizza, Andrea RiccioG. B. Ferrero

Research output: Contribution to journalArticle

Abstract

We provide data on fetal growth pattern on the molecular subtypes of Beckwith–Wiedemann syndrome (BWS): IC1 gain of methylation (IC1-GoM), IC2 loss of methylation (IC2-LoM), 11p15.5 paternal uniparental disomy (UPD), and CDKN1C mutation. In this observational study, gestational ages and neonatal growth parameters of 247 BWS patients were compared by calculating gestational age-corrected standard deviation scores (SDS) and proportionality indexes to search for differences among IC1-GoM (n = 21), UPD (n = 87), IC2-LoM (n = 147), and CDKN1C mutation (n = 11) patients. In IC1-GoM subgroup, weight and length are higher than in other subgroups. Body proportionality indexes display the following pattern: highest in IC1-GoM patients, lowest in IC2-LoM/CDKN1C patients, intermediate in UPD ones. Prematurity was significantly more prevalent in the CDKN1C (64%) and IC2-LoM subgroups (37%). Fetal growth patterns are different in the four molecular subtypes of BWS and remarkably consistent with altered gene expression primed by the respective molecular mechanisms. IC1-GoM cases show extreme macrosomia and severe disproportion between weight and length excess. In IC2-LoM/CDKN1C patients, macrosomia is less common and associated with more proportionate weight/length ratios with excess of preterm birth. UPD patients show growth patterns closer to those of IC2-LoM, but manifest a body mass disproportion rather similar to that seen in IC1-GoM cases.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalClinical Genetics
Volume90
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • Beckwith–Wiedemann
  • fetal growth
  • genotype
  • overgrowth
  • phenotype

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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  • Cite this

    Mussa, A., Russo, S., De Crescenzo, A., Freschi, A., Calzari, L., Maitz, S., Macchiaiolo, M., Molinatto, C., Baldassarre, G., Mariani, M., Tarani, L., Bedeschi, M. F., Milani, D., Melis, D., Bartuli, A., Vittoria Cubellis, M., Selicorni, A., Silengo, M. C., Larizza, L., ... Ferrero, G. B. (2016). Fetal growth patterns in Beckwith–Wiedemann syndrome. Clinical Genetics, 90(1), 21-27. https://doi.org/10.1111/cge.12759