Fetal heart pathology on postmortem 3-T magnetic resonance imaging

Inga Sandaite, Steven Dymarkowski, Luc De Catte, Philippe Moerman, Marc Gewillig, Luigi Fedele, Jan Deprest, Filip Claus

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Postmortem magnetic resonance imaging (pmMRI) is increasingly used in perinatology, typically as an alternative or complement to conventional necropsy for central nervous system anomalies. Overall, it provides reliable information on structural malformations but was shown to be of limited use in examining the fetal heart. Objective: We aimed to assess the fetal heart on 3-T pmMRI in a consecutive series of fetuses with structural congenital heart defects (CHD) and to determine diagnostic evaluation limits in case of CHD. Methods: A single-center database was retrospectively reviewed. Only fetuses having CHD of functional significance were included. Fetal cardiac anatomy was assessed on T2-weighted 3D multiplanar reconstructed images acquired using isovolumetric voxel size (0.3-0.8mm3), which allows to visualize cardiac structuresin situ in multiple fetal body planes. Cardiac pathology was classified into complex and isolated CHD. On the basis of clinically relevant findings, pmMRI was considered either diagnostic or not diagnostic. Results: A total of 24 fetuses were included in this study. The median gestational age was 22weeks and 2days (range 12w5d-34w6d). The median delay between delivery of the fetus and MR was 6h and 30min (range 1h and 30min-19h). PmMRI was diagnostic for 12 out of 13 (92.3%) complex CHD and for 6 out of 11 (54.5%) isolated CHD. In case of valvular malformation, a tentative diagnosis was reached in 7/11 cases (64%) on the basis of indirect features. Conclusions: Postmortem MRI is a valid diagnostic tool for CHD in fetuses beyond 16weeks up to term.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalPrenatal Diagnosis
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 2014

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology
  • Medicine(all)

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