Abstract
Over the last 18 years, we have developed the transplantation of fetal liver cells to treat severe immunodeficiencies, hematological disorders and inborn errors of metabolism. Post-natally, this treatment is successful in two-third of patients and it is therefore very valuable, especially when there is no perfectly matched donor for a bone marrow transplant. Since 1988 we have carried out these fetal liver transplants (FLTs) in utero, immediately after prenatal diagnosis. Engraftment and reconstitution have been obtained, and several advantages appear to be associated with in utero FLT: increased probability of graft take, ideal isolation of the patient (in the maternal uterus) and optimal environment for the differentiation of the transplanted fetal liver cells (in the fetal host).
| Original language | English |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | Bone Marrow Transplantation |
| Volume | 11 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Fetal liver transplantation : Biology and clinical results. / Touraine, J. L.; Roncarolo, M. G.; Bacchetta, R.; Raudrant, D.; Rebaud, A.; Laplace, S.; Cesbron, P.; Gebuhrer, L.; Zabot, M. T.; Touraine, F.; Frappaz, D.; Souillet, G.; Vullo, C.
In: Bone Marrow Transplantation, Vol. 11, No. SUPPL. 1, 1993, p. 119-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fetal liver transplantation
T2 - Biology and clinical results
AU - Touraine, J. L.
AU - Roncarolo, M. G.
AU - Bacchetta, R.
AU - Raudrant, D.
AU - Rebaud, A.
AU - Laplace, S.
AU - Cesbron, P.
AU - Gebuhrer, L.
AU - Zabot, M. T.
AU - Touraine, F.
AU - Frappaz, D.
AU - Souillet, G.
AU - Vullo, C.
PY - 1993
Y1 - 1993
N2 - Over the last 18 years, we have developed the transplantation of fetal liver cells to treat severe immunodeficiencies, hematological disorders and inborn errors of metabolism. Post-natally, this treatment is successful in two-third of patients and it is therefore very valuable, especially when there is no perfectly matched donor for a bone marrow transplant. Since 1988 we have carried out these fetal liver transplants (FLTs) in utero, immediately after prenatal diagnosis. Engraftment and reconstitution have been obtained, and several advantages appear to be associated with in utero FLT: increased probability of graft take, ideal isolation of the patient (in the maternal uterus) and optimal environment for the differentiation of the transplanted fetal liver cells (in the fetal host).
AB - Over the last 18 years, we have developed the transplantation of fetal liver cells to treat severe immunodeficiencies, hematological disorders and inborn errors of metabolism. Post-natally, this treatment is successful in two-third of patients and it is therefore very valuable, especially when there is no perfectly matched donor for a bone marrow transplant. Since 1988 we have carried out these fetal liver transplants (FLTs) in utero, immediately after prenatal diagnosis. Engraftment and reconstitution have been obtained, and several advantages appear to be associated with in utero FLT: increased probability of graft take, ideal isolation of the patient (in the maternal uterus) and optimal environment for the differentiation of the transplanted fetal liver cells (in the fetal host).
UR - http://www.scopus.com/inward/record.url?scp=0027460465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027460465&partnerID=8YFLogxK
M3 - Article
C2 - 8448534
AN - SCOPUS:0027460465
VL - 11
SP - 119
EP - 122
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - SUPPL. 1
ER -