Fetal liver transplantation: Biology and clinical results

J. L. Touraine; M. G. Roncarolo; R. Bacchetta; D. Raudrant; A. Rebaud; S. Laplace; P. Cesbron; L. Gebuhrer; M. T. Zabot; F. Touraine; D. Frappaz; G. Souillet; C. Vullo

Fetal liver transplantation: Biology and clinical results

J. L. Touraine, M. G. Roncarolo, R. Bacchetta, D. Raudrant, A. Rebaud, S. Laplace, P. Cesbron, L. Gebuhrer, M. T. Zabot, F. Touraine, D. Frappaz, G. Souillet, C. Vullo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Over the last 18 years, we have developed the transplantation of fetal liver cells to treat severe immunodeficiencies, hematological disorders and inborn errors of metabolism. Post-natally, this treatment is successful in two-third of patients and it is therefore very valuable, especially when there is no perfectly matched donor for a bone marrow transplant. Since 1988 we have carried out these fetal liver transplants (FLTs) in utero, immediately after prenatal diagnosis. Engraftment and reconstitution have been obtained, and several advantages appear to be associated with in utero FLT: increased probability of graft take, ideal isolation of the patient (in the maternal uterus) and optimal environment for the differentiation of the transplanted fetal liver cells (in the fetal host).

Original language	English
Pages (from-to)	119-122
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	11
Issue number	SUPPL. 1
Publication status	Published - 1993

ASJC Scopus subject areas

Hematology
Transplantation

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Touraine, J. L., Roncarolo, M. G., Bacchetta, R., Raudrant, D., Rebaud, A., Laplace, S., Cesbron, P., Gebuhrer, L., Zabot, M. T., Touraine, F., Frappaz, D., Souillet, G., & Vullo, C. (1993). Fetal liver transplantation: Biology and clinical results. Bone Marrow Transplantation, 11(SUPPL. 1), 119-122.

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abstract = "Over the last 18 years, we have developed the transplantation of fetal liver cells to treat severe immunodeficiencies, hematological disorders and inborn errors of metabolism. Post-natally, this treatment is successful in two-third of patients and it is therefore very valuable, especially when there is no perfectly matched donor for a bone marrow transplant. Since 1988 we have carried out these fetal liver transplants (FLTs) in utero, immediately after prenatal diagnosis. Engraftment and reconstitution have been obtained, and several advantages appear to be associated with in utero FLT: increased probability of graft take, ideal isolation of the patient (in the maternal uterus) and optimal environment for the differentiation of the transplanted fetal liver cells (in the fetal host).",

author = "Touraine, {J. L.} and Roncarolo, {M. G.} and R. Bacchetta and D. Raudrant and A. Rebaud and S. Laplace and P. Cesbron and L. Gebuhrer and Zabot, {M. T.} and F. Touraine and D. Frappaz and G. Souillet and C. Vullo",

year = "1993",

language = "English",

volume = "11",

pages = "119--122",

journal = "Bone Marrow Transplantation",

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AU - Touraine, J. L.

AU - Roncarolo, M. G.

AU - Bacchetta, R.

AU - Raudrant, D.

AU - Rebaud, A.

AU - Laplace, S.

AU - Cesbron, P.

AU - Gebuhrer, L.

AU - Zabot, M. T.

AU - Touraine, F.

AU - Frappaz, D.

AU - Souillet, G.

AU - Vullo, C.

PY - 1993

Y1 - 1993

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