Fetal lung maturity evaluation with fluorescence polarization of the amniotic fluid

Mario Salmona, Luisa Diomede, Guido Moro, Iolanda Minoli, Stefano Bernini, Silvano Agosti

Research output: Contribution to journalArticlepeer-review


Fluorescence polarization of the amniotic fluid from 39 high risk pregnancies requiring preterm delivery was measured in order to assess the maturity of the fetal lung. The study population included 15 cases of intrauterine growth retardation, ten maternal hypertension, five maternal Hodgkin's disease, three placenta previa, two fetal malformation, two polyamnios, one untreated diabetes, one maternal nephropathy. All patients underwent a single amniocentesis before deciding whether to deliver a preterm baby and FP of the amniotic fluid was done within two hours from amniocentesis. In five cases this was 0.311, the cut-off limit taken as an indicator of fetal pulmonary status, and three of these developed respiratory distress syndrome. In 34 cases FP values were <0.311; in spite of the apparent lung maturity two of these newborns developed respiratory distress syndrome. On the basis of these results the FP sensitivity was calculated as 60%, specificity 94% and the overall accuracy 90%.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Perinatal Medicine
Issue number5
Publication statusPublished - 1993


  • Amniotic fluid fetal lung maturity fluorescence polarization high risk pregnancies preterm delivery surfactant therapy. Fetale Lungenreife Fluoreszenspolarimetrie
  • Fruchtwasser Hochrisikoschwangerschaften Surfactant-Therapie vorzeitige Entbindung

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Fetal lung maturity evaluation with fluorescence polarization of the amniotic fluid'. Together they form a unique fingerprint.

Cite this