II rapporto immune materno-fetale in gravidanza

Translated title of the contribution: Fetal-maternal immune interaction in pregnancy

Francesco Tedesco, Mario Pausa, Roberta Bulla, Simona Melazzini, Secondo Guaschino

Research output: Contribution to journalArticle

Abstract

The mother establishes with the fetus a special interaction in pregnancy allowing his normal survival in spite of the different HLA antigens. The main factors contributing to these favourable conditions for the fetus are an efficient local immunosuppression and the formation of a protective barrier between the mother and the fetus. A number of substances are responsible for the local immunosuppression and include cytokines, prostaglandins, hormones as well as various other proteins of pregnancy. In addition, cytokines produced by TH2 lymphocytes seem to be predominant with respect to those of TH1 cells. An effective protection is provided by the trophoblast layer, which not only forms a physical barrier between the mother and the fetus but evades the immune attack of the mother by expressing inhibitory molecules of the complement system and by down regulating the expression of HLA antigens. Data obtained from murine models and clinical observation in pathological pregnancies suggest that an abnormal immune response of the mother against the feto-placental unit may be responsible for the occurrence of recurrent spontaneous abortions. This is proved by the ability of the partner's lymphocytes administered to females in the mouse model prior to mating to reduce the incidence of abortions. Unfortunately, similar treatment in women with recurrent abortion does not appear to be very effective.

Original languageItalian
Pages (from-to)406-414
Number of pages9
JournalRecenti Progressi in Medicina
Volume88
Issue number9
Publication statusPublished - Sep 1997

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tedesco, F., Pausa, M., Bulla, R., Melazzini, S., & Guaschino, S. (1997). II rapporto immune materno-fetale in gravidanza. Recenti Progressi in Medicina, 88(9), 406-414.