Fetal programming and systemic sclerosis

Gianpaolo Donzelli, Giulia Carnesecchi, Carolina Amador, Mariarosaria di Tommaso, Luca Filippi, Roberto Caporali, Veronica Codullo, Valeria Riccieri, Guido Valesini, Armando Gabrielli, Roberta Bagnati, Kathleen S. McGreevy, Salvatore De Masi, Marco Matucci Cerinic

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: This study investigated whether birthweight is linked to an increased risk of the development of systemic sclerosis.

STUDY DESIGN: This was a multicenter case-control study with perinatal data that were obtained from 332 cases with systemic sclerosis and 243 control subjects. Birthweight was treated as a dichotomous variable (

RESULTS: Significantly increased ORs were observed in the univariate analysis for low birthweight (OR, 2.59; 95% confidence interval [CI], 1.39-5.05) and small for gestational age (OR, 2.60; 95% CI, 1.34-5.32) subjects. Similarly increased risks were confirmed for both conditions in the multivariate analysis (OR, 3.93; 95% CI, 1.92-8.07; and OR, 2.58; 95% CI, 1.28-5.19), respectively.

CONCLUSION: Low birthweight and small for gestational age at birth are risk factors for the adult onset of systemic sclerosis.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume213
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Systemic Scleroderma
Fetal Development
Confidence Intervals
Gestational Age
Case-Control Studies
Multivariate Analysis
Parturition

Keywords

  • autoimmune disease
  • birthweight
  • epigenetics
  • fetal programming
  • scleroderma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Donzelli, G., Carnesecchi, G., Amador, C., di Tommaso, M., Filippi, L., Caporali, R., ... Matucci Cerinic, M. (2015). Fetal programming and systemic sclerosis. American Journal of Obstetrics and Gynecology, 213(6). https://doi.org/10.1016/j.ajog.2015.07.034

Fetal programming and systemic sclerosis. / Donzelli, Gianpaolo; Carnesecchi, Giulia; Amador, Carolina; di Tommaso, Mariarosaria; Filippi, Luca; Caporali, Roberto; Codullo, Veronica; Riccieri, Valeria; Valesini, Guido; Gabrielli, Armando; Bagnati, Roberta; McGreevy, Kathleen S.; De Masi, Salvatore; Matucci Cerinic, Marco.

In: American Journal of Obstetrics and Gynecology, Vol. 213, No. 6, 01.12.2015.

Research output: Contribution to journalArticle

Donzelli, G, Carnesecchi, G, Amador, C, di Tommaso, M, Filippi, L, Caporali, R, Codullo, V, Riccieri, V, Valesini, G, Gabrielli, A, Bagnati, R, McGreevy, KS, De Masi, S & Matucci Cerinic, M 2015, 'Fetal programming and systemic sclerosis', American Journal of Obstetrics and Gynecology, vol. 213, no. 6. https://doi.org/10.1016/j.ajog.2015.07.034
Donzelli, Gianpaolo ; Carnesecchi, Giulia ; Amador, Carolina ; di Tommaso, Mariarosaria ; Filippi, Luca ; Caporali, Roberto ; Codullo, Veronica ; Riccieri, Valeria ; Valesini, Guido ; Gabrielli, Armando ; Bagnati, Roberta ; McGreevy, Kathleen S. ; De Masi, Salvatore ; Matucci Cerinic, Marco. / Fetal programming and systemic sclerosis. In: American Journal of Obstetrics and Gynecology. 2015 ; Vol. 213, No. 6.
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