Fetal thymic differentiation in Down's syndrome

A. Cossarizza, D. Monti, G. Montagnani, A. Forabosco, B. F. Dagnaricarelli, C. Franceschi

Research output: Contribution to journalArticle

Abstract

Phenotypic features and proliferative ability of thymocytes, splenocytes and peripheral blood lymphocytes of 20-22 weeks human fetuses affected by Down's-syndrome (DS) were studied and compared to those of fetuses of the same gestational age with a normal karyotype. In the thymus of both DS and normal fetuses, the great majority of cells was CD1 +, CD2 +, CD5 +, CD4 +, CD8 +; using double fluorescence analysis, these markers could be detected on the same cell. About 50-60% showed CD3 antigen and about 40-50% presented the αβ T cell receptor. Thymocytes with NK markers (CD16, CD57, CD56) were not found. After stimulation with phytohemagglutin, thymocytes showed a low but detectable proliferative capability, while splenocytes and peripheral blood lymphocytes showed a high responsiveness to the mitogen. These data show that the impaired immune system in DS is not associated with gross abnormalities of phenotypic T cell development in the fetal thymus or with an inability of such fetal cells to proliferate after a mitogenic stimulus.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalThymus
Volume14
Issue number1-3
Publication statusPublished - 1989

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Thymocytes
Down Syndrome
Fetus
Thymus Gland
Lymphocytes
CD3 Antigens
Fetal Development
T-Cell Antigen Receptor
Karyotype
Mitogens
Gestational Age
Immune System
Fluorescence
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Cossarizza, A., Monti, D., Montagnani, G., Forabosco, A., Dagnaricarelli, B. F., & Franceschi, C. (1989). Fetal thymic differentiation in Down's syndrome. Thymus, 14(1-3), 163-170.

Fetal thymic differentiation in Down's syndrome. / Cossarizza, A.; Monti, D.; Montagnani, G.; Forabosco, A.; Dagnaricarelli, B. F.; Franceschi, C.

In: Thymus, Vol. 14, No. 1-3, 1989, p. 163-170.

Research output: Contribution to journalArticle

Cossarizza, A, Monti, D, Montagnani, G, Forabosco, A, Dagnaricarelli, BF & Franceschi, C 1989, 'Fetal thymic differentiation in Down's syndrome', Thymus, vol. 14, no. 1-3, pp. 163-170.
Cossarizza A, Monti D, Montagnani G, Forabosco A, Dagnaricarelli BF, Franceschi C. Fetal thymic differentiation in Down's syndrome. Thymus. 1989;14(1-3):163-170.
Cossarizza, A. ; Monti, D. ; Montagnani, G. ; Forabosco, A. ; Dagnaricarelli, B. F. ; Franceschi, C. / Fetal thymic differentiation in Down's syndrome. In: Thymus. 1989 ; Vol. 14, No. 1-3. pp. 163-170.
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