Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation

O. Falcon, C. F A Peralta, P. Cavoretto, M. Auer, K. H. Nicolaides

Research output: Contribution to journalArticle

Abstract

Objective: To examine the pattern of growth in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation and compare the trunk and head volume to crown-rump length (CRL) in defining the growth deficit in such fetuses. Methods: The fetal trunk and head volume was measured using three-dimensional (3D) ultrasound in 140 chromosomally abnormal fetuses at 11 + 0 to 13 + 6 (median 12) weeks of gestation, and the values were compared to 500 chromosomally normal fetuses. In each chromosomally abnormal fetus, the observed fetal trunk and head volume was subtracted from the expected mean (delta value) of the chromosomally normal fetuses of the same gestational age, and this difference was expressed as a percentage of the appropriate normal mean. The Mann-Whitney U-test was used to determine the significance of differences between the chromosomally normal and abnormal groups. Results: In trisomy 21 (n = 72) and Turner syndrome (n -14) fetuses, compared to chromosomally normal fetuses, the CRL for gestation was similar (P = 0.335 and P = 0.317, respectively), but the fetal trunk and head volume was about 10-15% lower (P <0.001 and P = 0.004, respectively). In trisomy 18 (n = 29), trisomy 13 (n = 14) and triploidy (n = 11), the deficit in volume was about 45% (P <0.001), whereas the deficit in CRL was less than 15% (P <0.001). Conclusions: In the quantification of the degree of early growth impairment in chromosomally abnormal fetuses, measurement of the fetal trunk and head volume using 3D ultrasound may be better than measurement of CRL.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalUltrasound in Obstetrics and Gynecology
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 2005

Fingerprint

fetuses
Fetus
Head
Pregnancy
Crown-Rump Length
Growth
Triploidy
Turner Syndrome
impairment
Nonparametric Statistics
Down Syndrome
Gestational Age
Reference Values

Keywords

  • 3D ultrasound
  • Chromosomal defects
  • Fetal volume
  • First trimester
  • Screening
  • VOCAL

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation. / Falcon, O.; Peralta, C. F A; Cavoretto, P.; Auer, M.; Nicolaides, K. H.

In: Ultrasound in Obstetrics and Gynecology, Vol. 26, No. 5, 10.2005, p. 517-520.

Research output: Contribution to journalArticle

Falcon, O. ; Peralta, C. F A ; Cavoretto, P. ; Auer, M. ; Nicolaides, K. H. / Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation. In: Ultrasound in Obstetrics and Gynecology. 2005 ; Vol. 26, No. 5. pp. 517-520.
@article{2c82e06dc6a44982af8ae3b2732110c7,
title = "Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation",
abstract = "Objective: To examine the pattern of growth in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation and compare the trunk and head volume to crown-rump length (CRL) in defining the growth deficit in such fetuses. Methods: The fetal trunk and head volume was measured using three-dimensional (3D) ultrasound in 140 chromosomally abnormal fetuses at 11 + 0 to 13 + 6 (median 12) weeks of gestation, and the values were compared to 500 chromosomally normal fetuses. In each chromosomally abnormal fetus, the observed fetal trunk and head volume was subtracted from the expected mean (delta value) of the chromosomally normal fetuses of the same gestational age, and this difference was expressed as a percentage of the appropriate normal mean. The Mann-Whitney U-test was used to determine the significance of differences between the chromosomally normal and abnormal groups. Results: In trisomy 21 (n = 72) and Turner syndrome (n -14) fetuses, compared to chromosomally normal fetuses, the CRL for gestation was similar (P = 0.335 and P = 0.317, respectively), but the fetal trunk and head volume was about 10-15{\%} lower (P <0.001 and P = 0.004, respectively). In trisomy 18 (n = 29), trisomy 13 (n = 14) and triploidy (n = 11), the deficit in volume was about 45{\%} (P <0.001), whereas the deficit in CRL was less than 15{\%} (P <0.001). Conclusions: In the quantification of the degree of early growth impairment in chromosomally abnormal fetuses, measurement of the fetal trunk and head volume using 3D ultrasound may be better than measurement of CRL.",
keywords = "3D ultrasound, Chromosomal defects, Fetal volume, First trimester, Screening, VOCAL",
author = "O. Falcon and Peralta, {C. F A} and P. Cavoretto and M. Auer and Nicolaides, {K. H.}",
year = "2005",
month = "10",
doi = "10.1002/uog.1990",
language = "English",
volume = "26",
pages = "517--520",
journal = "Ultrasound in Obstetrics and Gynecology",
issn = "0960-7692",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation

AU - Falcon, O.

AU - Peralta, C. F A

AU - Cavoretto, P.

AU - Auer, M.

AU - Nicolaides, K. H.

PY - 2005/10

Y1 - 2005/10

N2 - Objective: To examine the pattern of growth in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation and compare the trunk and head volume to crown-rump length (CRL) in defining the growth deficit in such fetuses. Methods: The fetal trunk and head volume was measured using three-dimensional (3D) ultrasound in 140 chromosomally abnormal fetuses at 11 + 0 to 13 + 6 (median 12) weeks of gestation, and the values were compared to 500 chromosomally normal fetuses. In each chromosomally abnormal fetus, the observed fetal trunk and head volume was subtracted from the expected mean (delta value) of the chromosomally normal fetuses of the same gestational age, and this difference was expressed as a percentage of the appropriate normal mean. The Mann-Whitney U-test was used to determine the significance of differences between the chromosomally normal and abnormal groups. Results: In trisomy 21 (n = 72) and Turner syndrome (n -14) fetuses, compared to chromosomally normal fetuses, the CRL for gestation was similar (P = 0.335 and P = 0.317, respectively), but the fetal trunk and head volume was about 10-15% lower (P <0.001 and P = 0.004, respectively). In trisomy 18 (n = 29), trisomy 13 (n = 14) and triploidy (n = 11), the deficit in volume was about 45% (P <0.001), whereas the deficit in CRL was less than 15% (P <0.001). Conclusions: In the quantification of the degree of early growth impairment in chromosomally abnormal fetuses, measurement of the fetal trunk and head volume using 3D ultrasound may be better than measurement of CRL.

AB - Objective: To examine the pattern of growth in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation and compare the trunk and head volume to crown-rump length (CRL) in defining the growth deficit in such fetuses. Methods: The fetal trunk and head volume was measured using three-dimensional (3D) ultrasound in 140 chromosomally abnormal fetuses at 11 + 0 to 13 + 6 (median 12) weeks of gestation, and the values were compared to 500 chromosomally normal fetuses. In each chromosomally abnormal fetus, the observed fetal trunk and head volume was subtracted from the expected mean (delta value) of the chromosomally normal fetuses of the same gestational age, and this difference was expressed as a percentage of the appropriate normal mean. The Mann-Whitney U-test was used to determine the significance of differences between the chromosomally normal and abnormal groups. Results: In trisomy 21 (n = 72) and Turner syndrome (n -14) fetuses, compared to chromosomally normal fetuses, the CRL for gestation was similar (P = 0.335 and P = 0.317, respectively), but the fetal trunk and head volume was about 10-15% lower (P <0.001 and P = 0.004, respectively). In trisomy 18 (n = 29), trisomy 13 (n = 14) and triploidy (n = 11), the deficit in volume was about 45% (P <0.001), whereas the deficit in CRL was less than 15% (P <0.001). Conclusions: In the quantification of the degree of early growth impairment in chromosomally abnormal fetuses, measurement of the fetal trunk and head volume using 3D ultrasound may be better than measurement of CRL.

KW - 3D ultrasound

KW - Chromosomal defects

KW - Fetal volume

KW - First trimester

KW - Screening

KW - VOCAL

UR - http://www.scopus.com/inward/record.url?scp=27744542037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744542037&partnerID=8YFLogxK

U2 - 10.1002/uog.1990

DO - 10.1002/uog.1990

M3 - Article

C2 - 16142826

AN - SCOPUS:27744542037

VL - 26

SP - 517

EP - 520

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 5

ER -