Fetal trunk and head volume in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation

O. Falcon, C. F A Peralta, P. Cavoretto, M. Auer, K. H. Nicolaides

Research output: Contribution to journalArticle

Abstract

Objective: To examine the pattern of growth in chromosomally abnormal fetuses at 11 + 0 to 13 + 6 weeks of gestation and compare the trunk and head volume to crown-rump length (CRL) in defining the growth deficit in such fetuses. Methods: The fetal trunk and head volume was measured using three-dimensional (3D) ultrasound in 140 chromosomally abnormal fetuses at 11 + 0 to 13 + 6 (median 12) weeks of gestation, and the values were compared to 500 chromosomally normal fetuses. In each chromosomally abnormal fetus, the observed fetal trunk and head volume was subtracted from the expected mean (delta value) of the chromosomally normal fetuses of the same gestational age, and this difference was expressed as a percentage of the appropriate normal mean. The Mann-Whitney U-test was used to determine the significance of differences between the chromosomally normal and abnormal groups. Results: In trisomy 21 (n = 72) and Turner syndrome (n -14) fetuses, compared to chromosomally normal fetuses, the CRL for gestation was similar (P = 0.335 and P = 0.317, respectively), but the fetal trunk and head volume was about 10-15% lower (P <0.001 and P = 0.004, respectively). In trisomy 18 (n = 29), trisomy 13 (n = 14) and triploidy (n = 11), the deficit in volume was about 45% (P <0.001), whereas the deficit in CRL was less than 15% (P <0.001). Conclusions: In the quantification of the degree of early growth impairment in chromosomally abnormal fetuses, measurement of the fetal trunk and head volume using 3D ultrasound may be better than measurement of CRL.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalUltrasound in Obstetrics and Gynecology
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 2005

Keywords

  • 3D ultrasound
  • Chromosomal defects
  • Fetal volume
  • First trimester
  • Screening
  • VOCAL

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

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