Fexofenadine reduces nasal congestion in perennial allergic rhinitis

G. Ciprandi, C. Cosentino, M. Milanese, C. Mondino, G. W. Canonica

Research output: Contribution to journalArticle

Abstract

Background: Nasal congestion is the predominant symptom in perennial allergic rhinitis (PAR), and it seems to be mainly related to the late-phase inflammatory events. The present pilot study aimed to evaluate the therapeutic effect exerted by fexofenadine in patients with PAR due to mite allergy. Methods: This study was a parallel, double-blind, randomized, three-arm (1:1:1), placebo-controlled study. Thirty-one subjects with PAR were enrolled and received double-blind medication: fexofenadine 120 or 180 mg, or placebo, once a day for 28 days. Results: The total symptom score was reduced by fexofenadine (both dosages) at V2 (P = 0.007), whereas placebo did not modify it. Nasal congestion decreased after 1 week of treatment with fexofenadine 120 (P = 0.027) and 180 (P = 0.01), but not with placebo (P = NS). At V3, fexofenadine (both dosages) significantly reduced nasal congestion (P = 0.011 and P = 0.007, respectively), by placebo did not show any significant effect. Conclusions: This pilot study represents the first evidence of the efficacy of fexofenadine in PAR, and also the control of the nasal congestion. We suggest performing larger trials to confirm these preliminary findings.

Original languageEnglish
Pages (from-to)1068-1070
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume56
Issue number11
DOIs
Publication statusPublished - 2001

Keywords

  • Fexofenadine
  • Perennial allergic rhinitis

ASJC Scopus subject areas

  • Immunology

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