FFT approximation in Alzheimer's disease

C. Fornara, M. Cursi, L. Roveri, F. Minicucci, T. Locatelli, G. Comi

Research output: Contribution to journalArticle

Abstract

The electroencephalographic modifications that occur during the course of Alzheimer's disease are characterised by an increase in the potential of low frequency bands, a diminution in the potential of alpha activity, and a change in the topographical distribution of the potential of all band frequencies. In this study, the fast Fourier transform (FFT) approximation was used to characterise modifications in the electroencephalogram location or orientation of the source of the dipole equivalent of the delta, theta, alpha 1, alpha2, beta1 and beta2 frequencies in 20 with patients with Alzheimer's disease and in a control group of 20 age-matched subjects. A statistical (t-test) comparison of the two groups revealed a significant change in the location of the dipolar source along the vertical axis in 18 (90%) of the patients; this change involved all the frequency bands. There was also a significant movement of the dipolar source of the alpha 1 band towards the anterior regions. In addition, the control group showed that there was a significant correlation between age and a more surface expression of the source of the delta, theta, alpha 1 and beta 1 bands.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume19
Issue number4
Publication statusPublished - 1998

Keywords

  • Alzheimer's disease
  • FFT dipole approximation
  • Quantified EEG

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

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  • Cite this

    Fornara, C., Cursi, M., Roveri, L., Minicucci, F., Locatelli, T., & Comi, G. (1998). FFT approximation in Alzheimer's disease. Italian Journal of Neurological Sciences, 19(4), 211-216.