FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer

Monica Spinola, Vera Piera Leoni, Jun Ichi Tanuma, Angela Pettinicchio, Milo Frattini, Stefano Signoroni, Roberto Agresti, Riccardo Giovanazzi, Silvana Pilotti, Lucio Bertario, Fernando Ravagnani, Tommaso A. Dragani

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Abstract

A functional Gly388Arg variation in the FGFR4 gene has been reported to be associated with breast and colorectal cancer prognostic parameters. To further examine the functional role of this genetic polymorphism at the population level, we assessed the presence of the Arg388 allele in 142 breast carcinoma patients, 179 colorectal carcinoma patients and 220 general population controls with respect to an association with cancer prognosis and/or risk. No significant association with cancer risk, survival or any other prognostic parameters was observed in either breast or colorectal cancer. A pooled analysis of the present and published data on nodal status by FGFR4 genotypes revealed no association in either breast cancer [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.7-1.4; 702 subjects] or colorectal cancer (OR, 1.4; 95% CI, 0.6-3.4; 260 cases). Thus, the FGFR4 polymorphism may not be relevant in predicting nodal involvement of breast cancer or colon cancer patients.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalOncology Reports
Volume14
Issue number2
Publication statusPublished - Aug 2005

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Colorectal Neoplasms
Breast Neoplasms
Colonic Neoplasms
Odds Ratio
Confidence Intervals
Population Control
Genetic Polymorphisms
Neoplasms
Alleles
Genotype
Survival
Population
Genes

Keywords

  • Fibroblast growth factor receptor 4
  • Genetic polymorphisms
  • Genetic predisposition

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Spinola, M., Leoni, V. P., Tanuma, J. I., Pettinicchio, A., Frattini, M., Signoroni, S., ... Dragani, T. A. (2005). FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Oncology Reports, 14(2), 415-419.

FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. / Spinola, Monica; Leoni, Vera Piera; Tanuma, Jun Ichi; Pettinicchio, Angela; Frattini, Milo; Signoroni, Stefano; Agresti, Roberto; Giovanazzi, Riccardo; Pilotti, Silvana; Bertario, Lucio; Ravagnani, Fernando; Dragani, Tommaso A.

In: Oncology Reports, Vol. 14, No. 2, 08.2005, p. 415-419.

Research output: Contribution to journalArticle

Spinola, M, Leoni, VP, Tanuma, JI, Pettinicchio, A, Frattini, M, Signoroni, S, Agresti, R, Giovanazzi, R, Pilotti, S, Bertario, L, Ravagnani, F & Dragani, TA 2005, 'FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer', Oncology Reports, vol. 14, no. 2, pp. 415-419.
Spinola M, Leoni VP, Tanuma JI, Pettinicchio A, Frattini M, Signoroni S et al. FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Oncology Reports. 2005 Aug;14(2):415-419.
Spinola, Monica ; Leoni, Vera Piera ; Tanuma, Jun Ichi ; Pettinicchio, Angela ; Frattini, Milo ; Signoroni, Stefano ; Agresti, Roberto ; Giovanazzi, Riccardo ; Pilotti, Silvana ; Bertario, Lucio ; Ravagnani, Fernando ; Dragani, Tommaso A. / FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. In: Oncology Reports. 2005 ; Vol. 14, No. 2. pp. 415-419.
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