Fiber intake and endometrial cancer risk

Ettore Bidoli, Claudio Pelucchi, Antonella Zucchetto, Eva Negri, Luigino Dal Maso, Jerry Polesel, Maurizio Montella, Silvia Franceschi, Diego Serraino, Carlo La Vecchia, Renato Talamini

Research output: Contribution to journalArticlepeer-review


Background. The epidemiological evidence on the relation between dietary fiber intake and endometrial cancer is contradictory. Consequently, a case-control study was carried out to further investigate the role of dietary fiber intake in the etiology of endometrial cancer. Material and methods. Cases were 454 women with incident, histologically confirmed, endometrial cancer admitted to major teaching and general hospitals. Controls were 908 women admitted for acute, non-neoplastic conditions to the same hospital network. Information on diet was elicited using a validated food frequency questionnaire. Results. Odds ratios (OR) and 95% confidence intervals (CI) for quintiles of various types of fiber were estimated after allowance for total energy intake and other potential confounding factors. Lignin intake was significantly inversely related to endometrial cancer (OR=0.6 for the highest versus the lowest quintile of intake; 95%CI: 0.4-0.9) with a slightly significant linear trend in risk (p-value=0.04). Discussion. Data suggest the potential importance of lignin in the prevention of endometrial cancer at Italian consumption levels.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalActa Oncologica
Issue number4
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology


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