TY - JOUR
T1 - Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort
AU - Chuang, Shu Chun
AU - Norat, Teresa
AU - Murphy, Neil
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Perquier, Florence
AU - Dartois, Laureen
AU - Kaaks, Rudolf
AU - Teucher, Birgit
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Grioni, Sara
AU - Sacerdote, Carlotta
AU - Panico, Salvatore
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Peeters, Petra H M
AU - Bueno-de-Mesquita, Bas
AU - Ros, Martine M.
AU - Brustad, Magritt
AU - Åsli, Lene Angell
AU - Skeie, Guri
AU - Quirós, J. Ramón
AU - González, Carlos A.
AU - Sánchez, María José
AU - Navarro, Carmen
AU - Aicua, Eva Ardanaz
AU - Dorronsoro, Miren
AU - Drake, Isabel
AU - Sonestedt, Emily
AU - Johansson, Ingegerd
AU - Hallmans, Göran
AU - Key, Timothy
AU - Crowe, Francesca
AU - Khaw, Kay Tee
AU - Wareham, Nicholas
AU - Ferrari, Pietro
AU - Slimani, Nadia
AU - Romieu, Isabelle
AU - Gallo, Valentina
AU - Riboli, Elio
AU - Vineis, Paolo
PY - 2012/7
Y1 - 2012/7
N2 - Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,717 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper 10-g/d increase: 0.90; 95% CI: 0.88, 0.92); with mortality from circulatory (HRper 10-g/d increase: 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance.
AB - Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,717 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper 10-g/d increase: 0.90; 95% CI: 0.88, 0.92); with mortality from circulatory (HRper 10-g/d increase: 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance.
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U2 - 10.3945/ajcn.111.028415
DO - 10.3945/ajcn.111.028415
M3 - Article
C2 - 22648726
AN - SCOPUS:84863601547
VL - 96
SP - 164
EP - 174
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 1
ER -