Fiber intake modulates the association of alcohol intake with breast cancer.

Isabelle Romieu; Pietro Ferrari; Veronique Chajes; Jordi De Batlle; Carine Biessy; Chiara Scoccianti; Laure Dossus; Marie Christine Boutron; Nadia Bastide; Kim Overvad; Anja Olsen; Anne Tjonneland; Rudolf Kaaks; Heiner Boeing; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Domenico Palli; Sabina Sieri; Rosario Tumino; Paolo Vineis; Salvatore Panico; H B as Bueno-de-Mesquita; Carla H Van Gils; Petra P H Peeters; Eiliv Lund; Guri Skeie; Elisabete Weiderpass; J. Ramon Quiros; Maria Dolores Chirlaque Lopez; Eva Ardanaz; Maria-Jose Sanchez; Eric J. Duell; Pilar Amiano Etxezarreta; Signe Borgquist; Goran Hallmans; Ingegerd Johansson; Lena Maria Nilsson; Kay Tee Khaw; Nick Wareham; Timothy J. Key; Ruth C. Travis; Neil Murphy; Petra A. Wark; Elio Riboli

doi:10.1002/ijc.30415

Fiber intake modulates the association of alcohol intake with breast cancer.

Isabelle Romieu, Pietro Ferrari, Veronique Chajes, Jordi De Batlle, Carine Biessy, Chiara Scoccianti, Laure Dossus, Marie Christine Boutron, Nadia Bastide, Kim Overvad, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario TuminoPaolo Vineis, Salvatore Panico, H B as Bueno-de-Mesquita, Carla H Van Gils, Petra P H Peeters, Eiliv Lund, Guri Skeie, Elisabete Weiderpass, J. Ramon Quiros, Maria Dolores Chirlaque Lopez, Eva Ardanaz, Maria-Jose Sanchez, Eric J. Duell, Pilar Amiano Etxezarreta, Signe Borgquist, Goran Hallmans, Ingegerd Johansson, Lena Maria Nilsson, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Ruth C. Travis, Neil Murphy, Petra A. Wark, Elio Riboli

Research output: Contribution to journal › Article › peer-review

Abstract

Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (textless18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (textgreater24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (textless18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

Original language	Undefined/Unknown
Pages (from-to)	316-321
Number of pages	6
Journal	International Journal of Cancer
Volume	140
Issue number	2
DOIs	https://doi.org/10.1002/ijc.30415
Publication status	Published - Jan 1 2017

Keywords

Alcohol, Breast cancer, Epidemiology, Nutrition

Access to Document

10.1002/ijc.30415

Cite this

Romieu, I., Ferrari, P., Chajes, V., De Batlle, J., Biessy, C., Scoccianti, C., Dossus, L., Christine Boutron, M., Bastide, N., Overvad, K., Olsen, A., Tjonneland, A., Kaaks, R., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., ... Riboli, E. (2017). Fiber intake modulates the association of alcohol intake with breast cancer. International Journal of Cancer, 140(2), 316-321. https://doi.org/10.1002/ijc.30415

Fiber intake modulates the association of alcohol intake with breast cancer. / Romieu, Isabelle; Ferrari, Pietro; Chajes, Veronique; De Batlle, Jordi; Biessy, Carine; Scoccianti, Chiara; Dossus, Laure; Christine Boutron, Marie; Bastide, Nadia; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Kaaks, Rudolf; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H B as; Gils, Carla H Van; Peeters, Petra P H; Lund, Eiliv; Skeie, Guri; Weiderpass, Elisabete; Ramon Quiros, J.; Chirlaque Lopez, Maria Dolores; Ardanaz, Eva; Sanchez, Maria-Jose; Duell, Eric J.; Amiano Etxezarreta, Pilar; Borgquist, Signe; Hallmans, Goran; Johansson, Ingegerd; Maria Nilsson, Lena; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Travis, Ruth C.; Murphy, Neil; Wark, Petra A.; Riboli, Elio.

In: International Journal of Cancer, Vol. 140, No. 2, 01.01.2017, p. 316-321.

Research output: Contribution to journal › Article › peer-review

Romieu, I, Ferrari, P, Chajes, V, De Batlle, J, Biessy, C, Scoccianti, C, Dossus, L, Christine Boutron, M, Bastide, N, Overvad, K, Olsen, A, Tjonneland, A, Kaaks, R, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, HBA, Gils, CHV, Peeters, PPH, Lund, E, Skeie, G, Weiderpass, E, Ramon Quiros, J, Chirlaque Lopez, MD, Ardanaz, E, Sanchez, M-J, Duell, EJ, Amiano Etxezarreta, P, Borgquist, S, Hallmans, G, Johansson, I, Maria Nilsson, L, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Murphy, N, Wark, PA & Riboli, E 2017, 'Fiber intake modulates the association of alcohol intake with breast cancer.', International Journal of Cancer, vol. 140, no. 2, pp. 316-321. https://doi.org/10.1002/ijc.30415

Romieu, Isabelle ; Ferrari, Pietro ; Chajes, Veronique ; De Batlle, Jordi ; Biessy, Carine ; Scoccianti, Chiara ; Dossus, Laure ; Christine Boutron, Marie ; Bastide, Nadia ; Overvad, Kim ; Olsen, Anja ; Tjonneland, Anne ; Kaaks, Rudolf ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Bueno-de-Mesquita, H B as ; Gils, Carla H Van ; Peeters, Petra P H ; Lund, Eiliv ; Skeie, Guri ; Weiderpass, Elisabete ; Ramon Quiros, J. ; Chirlaque Lopez, Maria Dolores ; Ardanaz, Eva ; Sanchez, Maria-Jose ; Duell, Eric J. ; Amiano Etxezarreta, Pilar ; Borgquist, Signe ; Hallmans, Goran ; Johansson, Ingegerd ; Maria Nilsson, Lena ; Khaw, Kay Tee ; Wareham, Nick ; Key, Timothy J. ; Travis, Ruth C. ; Murphy, Neil ; Wark, Petra A. ; Riboli, Elio. / Fiber intake modulates the association of alcohol intake with breast cancer. In: International Journal of Cancer. 2017 ; Vol. 140, No. 2. pp. 316-321.

@article{c267bb5f9ba449a6b02479a523f1e784,

title = "Fiber intake modulates the association of alcohol intake with breast cancer.",

abstract = "Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (textless18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (textgreater24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (textless18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.",

keywords = "Alcohol, Breast cancer, Epidemiology, Nutrition",

author = "Isabelle Romieu and Pietro Ferrari and Veronique Chajes and {De Batlle}, Jordi and Carine Biessy and Chiara Scoccianti and Laure Dossus and {Christine Boutron}, Marie and Nadia Bastide and Kim Overvad and Anja Olsen and Anne Tjonneland and Rudolf Kaaks and Heiner Boeing and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Domenico Palli and Sabina Sieri and Rosario Tumino and Paolo Vineis and Salvatore Panico and Bueno-de-Mesquita, {H B as} and Gils, {Carla H Van} and Peeters, {Petra P H} and Eiliv Lund and Guri Skeie and Elisabete Weiderpass and {Ramon Quiros}, J. and {Chirlaque Lopez}, {Maria Dolores} and Eva Ardanaz and Maria-Jose Sanchez and Duell, {Eric J.} and {Amiano Etxezarreta}, Pilar and Signe Borgquist and Goran Hallmans and Ingegerd Johansson and {Maria Nilsson}, Lena and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Travis, {Ruth C.} and Neil Murphy and Wark, {Petra A.} and Elio Riboli",

year = "2017",

month = jan,

day = "1",

doi = "10.1002/ijc.30415",

language = "Non definita",

volume = "140",

pages = "316--321",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Fiber intake modulates the association of alcohol intake with breast cancer.

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Chajes, Veronique

AU - De Batlle, Jordi

AU - Biessy, Carine

AU - Scoccianti, Chiara

AU - Dossus, Laure

AU - Christine Boutron, Marie

AU - Bastide, Nadia

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjonneland, Anne

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, H B as

AU - Gils, Carla H Van

AU - Peeters, Petra P H

AU - Lund, Eiliv

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Ramon Quiros, J.

AU - Chirlaque Lopez, Maria Dolores

AU - Ardanaz, Eva

AU - Sanchez, Maria-Jose

AU - Duell, Eric J.

AU - Amiano Etxezarreta, Pilar

AU - Borgquist, Signe

AU - Hallmans, Goran

AU - Johansson, Ingegerd

AU - Maria Nilsson, Lena

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Murphy, Neil

AU - Wark, Petra A.

AU - Riboli, Elio

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (textless18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (textgreater24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (textless18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

AB - Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (textless18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03-1.08) while among subjects with high intake of fiber (textgreater24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (textless18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

KW - Alcohol, Breast cancer, Epidemiology, Nutrition

U2 - 10.1002/ijc.30415

DO - 10.1002/ijc.30415

M3 - Articolo

VL - 140

SP - 316

EP - 321

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -