Fibre intake and prostate cancer risk

Claudio Pelucchi, Renato Talamini, Carlotta Galeone, Eva Negri, Silvia Franceschi, Luigino Dal Maso, Maurizio Montella, Ettore Conti, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Dietary fibre has been reported to protect from several neoplasms, but the issue remains controversial. No previous study considered in depth the topic of fibres and prostate cancer. A multicentre case-control study was conducted in Italy from 1991 to 2002, including 1,294 men with incident, histologically confirmed prostate cancer and 1,451 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. Compared to the lowest quintile, the OR of prostate cancer for the highest quintile of total fibre intake was 0.93 (95% CI 0.71-1.22). The risk was inversely related with soluble fibre (OR = 0.89, 95% CI 0.78-1.02, for a difference between 80th and 20th percentile), cellulose (OR = 0.88, 95% CI 0.78-1.01) and vegetable fibre (OR = 0.82, 95% CI 0.73-0.93). These relationships were consistent across strata of age, family history of prostate cancer, body mass index and education. Vegetable fibres appear, therefore, to have a favourable association with prostate cancer risk.

Original languageEnglish
Pages (from-to)278-280
Number of pages3
JournalInternational Journal of Cancer
Volume109
Issue number2
DOIs
Publication statusPublished - Mar 20 2004

Keywords

  • Cancer risk
  • Case-control studies
  • Diet
  • Dietary fibre
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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