Fibrin clot retractile activity in normal, established, and tumorigenic human epithelial cells in culture

B. Azzarone, A. Macieira-Coelho, L. Curatolo, D. Brouty-Boyé, O. Varnier, M. B. Donati, L. Morasca

Research output: Contribution to journalArticlepeer-review

Abstract

Normal and established human epithelial cell lines obtained from the same organs were compared for their capacity to retract a fibrin clot. Fibrin clot retraction was maximal in normal epithelial cells, reduced in established nontumorigenic lines, and lost in tumorigenic cancer cell lines. Fibrin clot retraction efficiency seemed to be related to the degree of cellular spreading within the clot at the end of the test. Previous works and the present study suggest that fibrin clot retraction is correlated with some steps of cell transformation in vitro.

Original languageEnglish
Pages (from-to)879-885
Number of pages7
JournalJournal of the National Cancer Institute
Volume71
Issue number5
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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