Abstract
Normal avian embryo fibroblasts induced retraction of a fibrin clot. The expression of high levels of this activity was associated with the exponential growth phase of the cell division cycle. Cells transformed by avian sarcoma virus (ASV) and other agents lost this activity regardless of the cell cycle phase. Cultures infected with transformation-defective ASV mutants retained a high level of fibrin clot retraction. However, this activity could not be recovered when temperature-sensitive, virus-transformed cells were shifted to a nonpermissive temperature (41°C). The results indicated that, in this cell system, loss of fibrin clot retraction could be considered a reliable parameter of cell transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 89-94 |
| Number of pages | 6 |
| Journal | Journal of the National Cancer Institute |
| Volume | 67 |
| Issue number | 1 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Fibrin clot retraction in normal and transformed avian fibroblasts. / Azzarone, B.; Curatolo, C.; Carloni, G.; Doanti, M. B.; Morasca, L.; Macieira-Coelho, A.
In: Journal of the National Cancer Institute, Vol. 67, No. 1, 1981, p. 89-94.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibrin clot retraction in normal and transformed avian fibroblasts
AU - Azzarone, B.
AU - Curatolo, C.
AU - Carloni, G.
AU - Doanti, M. B.
AU - Morasca, L.
AU - Macieira-Coelho, A.
PY - 1981
Y1 - 1981
N2 - Normal avian embryo fibroblasts induced retraction of a fibrin clot. The expression of high levels of this activity was associated with the exponential growth phase of the cell division cycle. Cells transformed by avian sarcoma virus (ASV) and other agents lost this activity regardless of the cell cycle phase. Cultures infected with transformation-defective ASV mutants retained a high level of fibrin clot retraction. However, this activity could not be recovered when temperature-sensitive, virus-transformed cells were shifted to a nonpermissive temperature (41°C). The results indicated that, in this cell system, loss of fibrin clot retraction could be considered a reliable parameter of cell transformation.
AB - Normal avian embryo fibroblasts induced retraction of a fibrin clot. The expression of high levels of this activity was associated with the exponential growth phase of the cell division cycle. Cells transformed by avian sarcoma virus (ASV) and other agents lost this activity regardless of the cell cycle phase. Cultures infected with transformation-defective ASV mutants retained a high level of fibrin clot retraction. However, this activity could not be recovered when temperature-sensitive, virus-transformed cells were shifted to a nonpermissive temperature (41°C). The results indicated that, in this cell system, loss of fibrin clot retraction could be considered a reliable parameter of cell transformation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019471037&partnerID=8YFLogxK
M3 - Article
C2 - 6265684
AN - SCOPUS:0019471037
VL - 67
SP - 89
EP - 94
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 1
ER -