Fibrin glue improves osteochondral scaffold fixation: Study on the human cadaveric knee exposed to continuous passive motion

G. Filardo, M. Drobnic, F. Perdisa, E. Kon, M. Hribernik, M. Marcacci

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate stability and integrity of bi-layer and three-layer collagen-hydroxyapatite (C-HA) osteochondral scaffolds in a human cadaveric knee exposed to continuous passive motion (CPM) with and without loading and the role of added fibrin glue to improve the press-fit fixation of C-HA scaffolds. Design: Osteochondral lesions (2.0×1.5cm) were chiseled out on both condyles and trochlea in eight human cadaveric knees. A total of 24 bi-layer (5mm, four in each condyle) or three-layer C-HA scaffolds (8mm, eight in the trochlea, four in each condyle) were first press-fit implanted and underwent testing with CPM, 90 cycles, 0°-90°. The second set of 24 scaffolds was implanted in cleaned lesions with the addition of fibrin glue. Two knees with fibrin glue fixation were additionally exposed to 15kg loading, with 30 cycles of CPM, 0°-30°. Then, the knees were reopened and the scaffolds were evaluated using semi-quantitative Drobnic and modified Bekkers scores. Results: All but two scaffolds remained in the lesions site throughout CPM. Two implants failed: both were bi-layer osteochondral scaffolds, press-fit implanted at the lateral femoral condyle (LFC). A statistically significant difference was obtained between press-fit and fibrin glue implants with both Drobnic (2.9±0.7 vs 4.3±0.1, P

Original languageEnglish
Pages (from-to)557-565
Number of pages9
JournalOsteoarthritis and Cartilage
Volume22
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Articular cartilage lesion
  • Fibrin glue
  • Knee joint
  • Osteochondral scaffold
  • Post-operative rehabilitation
  • Scaffold fixation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Fibrin glue improves osteochondral scaffold fixation: Study on the human cadaveric knee exposed to continuous passive motion'. Together they form a unique fingerprint.

Cite this