Fibrinogen and Factor Vllag in Healthy Adolescents: The Floren-teen (Florence Teenager) Study

Domenico Prisco, Sandra Fedi, Tamara Brunelli, Anna Paola Cellal, Mohamed Isse Hagi, Roberto Gianni, Emilio Santoro, Carlo Cappelletti, Guglielmina Pepe, Gian Franco Gensini, Rosanna Abbate

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At least five studies based on more than twenty thousand healthy subjects indicated that fibrinogen is an independent risk factor for cardiovascular events; less clear-cut is the relation between factor VII and risk for arterial thrombotic disorders, which was demonstrated in two of the three studies investigating this association. However, no study has investigated the behaviour of fibrinogen and factor VII in an adolescent population. In a study of Preventive Medicine and Education Program, fibrinogen (clotting method) and factor VIIag (ELISA), in addition to other metabolic parameters, life-style and familìal history, were investigated in 451 students (313 females and 138 males, age 15-17 years) from two high schools of Florence. Fibrinogen levels were significantly higher in women than in men, whereas factor VIIag levels did not significantly differ. Both fibrinogen and factor VIIag significantly correlated with total cholesterol (p

Original languageEnglish
Pages (from-to)778-781
Number of pages4
JournalThrombosis and Haemostasis
Issue number5
Publication statusPublished - May 1996

ASJC Scopus subject areas

  • Hematology


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