Fibrinogen and mechanisms of thrombosis. A difficult link

G. Di Minno, A. Cerbone, M. Margaglione, G. Vecchione, E. Grandone, M. Mancini

Research output: Contribution to journalArticlepeer-review


Epidemiological observations indicate that high plasma fibrinogen levels are strongly correlated to the frequency of two major thrombotic complications of atherosclerosis: stroke and myocardial infarction. Thrombosis is increasingly recognized as a central mechanism in stroke and myocardial infartion, and fibrinogen is involved in events thought to play a major role in thrombosis. Therefore, elucidation of the relationship between fibrinogen and thrombosis may strengthen the predictive value of this protein and define new interventions against stroke and myocardial infarction. In addition, advances in the understanding of the atherogenic potential of several risk factors of coronary heart disease took advantage of information emerging from the measurement of the factor in population-based studies. Thus, it is conceivable that measuring plasma fibrinogen to predict stroke and myocardial infarction is a major direction to be followed to gain insight into the thrombogenic potential on this protein and inspire new strategies against thrombotic complications of atherosclerosis.

Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalEuropean Journal of Epidemiology
Issue number1 Supplement
Publication statusPublished - May 1992


  • Fibrinogen
  • Myocardial Infarction
  • Risk
  • Stroke
  • Thrombosis

ASJC Scopus subject areas

  • Epidemiology


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