Fibrinogen inclusions in liver cells: A new type of ground-glass hepatocyte. Immune light and electron microscopic characterization

F. Callea, R. de Vos, R. Togni, R. Tardanico, M. J. Vanstapel, V. J. Desmet

Research output: Contribution to journalArticle

Abstract

A new type of ground-glass hepatocyte is described. The appearance is due to pale, homogenous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoyxlin and eosin stained sections, these cells closely resemble ground-glass hepatocytes described in other conditions. However, they are negative on special stains for HGsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen. On electron microscopy, the immunoreactive fibrinogen appears as amorphous, fluffy or granular material within dilated cisternae of the rough endoplasmic reticulum. This finding suggests intracellular storage possibly reflecting a defective intracellular transport of fibrinogen.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalHistopathology
Volume10
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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